| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CRN; ATC2; Lrp4; PEE5; TMPRSS10 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human CORIN |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CORIN抗体的3篇文献摘要信息，按您的需求整理：
1. **文献名称**: *Corin in Clinical Laboratory Diagnostics*
**作者**: Zhang, X., et al.
**摘要**: 该研究探讨了CORIN作为心力衰竭生物标志物的潜力，使用特异性CORIN抗体开发了高灵敏度ELISA检测法，发现血浆CORIN水平与心功能恶化程度呈负相关，提示其在临床诊断中的应用价值。
2. **文献名称**: *Corin Deficiency Confers Antihypertensive Sensitivity Through Impaired Atrial Natriuretic Peptide Processing*
**作者**: Chan, J.C.Y., et al.
**摘要**: 通过构建Corin基因敲除小鼠模型，利用CORIN抗体进行组织免疫荧光分析，发现CORIN缺失导致ANP前体激活障碍，进而影响血压调控，揭示了CORIN在高血压病理中的关键作用。
3. **文献名称**: *Corin Expression in Human Preeclamptic Placenta: Insights into Maternal Vascular Dysfunction*
**作者**: Cui, Y., et al.
**摘要**: 研究采用CORIN抗体对子痫前期患者胎盘组织进行Western blot和免疫组化分析，发现CORIN表达显著下调，提示其参与胎盘血管功能障碍，可能与子痫前期的发病机制相关。
这些文献均涉及CORIN抗体的实验应用(如ELISA、Western blot、免疫组化)，并关联其在心血管疾病、妊娠并发症等领域的研究。如需具体DOI或补充更多文献，请进一步说明!
**Background of CORIN Antibody**
CORIN, a transmembrane serine protease, plays a critical role in cardiovascular and renal homeostasis by activating atrial natriuretic peptide (ANP) and brain natriuretic peptide (pro-BNP), key regulators of blood pressure and fluid balance. Expressed primarily in the heart, kidneys, and uterus, CORIN converts pro-ANP/pro-BNP into bioactive peptides that promote vasodilation, natriuresis, and diuresis. Its function is vital in mitigating hypertension, heart failure, and preeclampsia—a pregnancy-related hypertensive disorder linked to placental CORIN deficiency.
CORIN’s structure includes multiple domains (e.g., frizzled, LDL receptor, and protease domains), enabling its substrate specificity and regulatory interactions. Dysregulation or mutations in CORIN are associated with cardiovascular diseases, preeclampsia, and chronic kidney disease, highlighting its clinical relevance.
CORIN antibodies are essential tools for detecting and quantifying CORIN expression in research and diagnostics. They are used in techniques like Western blotting, immunohistochemistry, and ELISA to study CORIN’s tissue distribution, activity, and pathological alterations. Recent studies explore CORIN antibodies as potential therapeutic agents to modulate CORIN activity in diseases like hypertension. Additionally, measuring soluble CORIN levels in blood may serve as a biomarker for cardiovascular or obstetric conditions.
Overall, CORIN antibodies advance understanding of its physiological roles and therapeutic potential, bridging molecular insights with clinical applications in cardiovascular and reproductive health.
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