| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CR; TC; DAF; CROM |
| Entrez GeneID | 1604 |
| clone | 3F12 |
| WB Predicted band size | 41.4kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD55 (AA: 238-357) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇与CPA2抗体相关的示例文献(内容为模拟概括，仅供参考)：
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1. **文献名称**: *Carboxypeptidase A2 (CPA2) autoantibodies in early-stage pancreatic cancer: diagnostic potential and epitope mapping*
**作者**: Smith J, et al.
**摘要**: 本研究探讨了CPA2自身抗体作为胰腺癌早期生物标志物的潜力。通过ELISA和蛋白质微阵列技术，发现胰腺癌患者血清中抗CPA2 IgG水平显著高于健康对照组，并鉴定了两个主要抗原表位区域，提示其可能用于辅助诊断。
2. **文献名称**: *Structural characterization of CPA2 and development of monoclonal antibodies for functional inhibition*
**作者**: Li X, et al.
**摘要**: 报道了羧肽酶A2(CPA2)的晶体结构解析，并基于其活性位点设计单克隆抗体。实验显示，筛选到的抗体可特异性结合CPA2并抑制其酶活，为研究CPA2在消化系统疾病中的作用提供了工具。
3. **文献名称**: *CPA2 expression and antibody-based detection in chronic pancreatitis tissues*
**作者**: Gonzalez R, et al.
**摘要**: 通过免疫组化分析慢性胰腺炎组织中CPA2的表达模式，开发了一种高特异性兔多克隆抗体。研究发现CPA2在病变腺泡细胞中异常高表达，提示其可能参与胰腺炎症进程。
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**注**：以上为示例性内容，实际文献需通过PubMed/Google Scholar等平台检索关键词(如"CPA2 antibody"、"carboxypeptidase A2 immunoassay")。建议结合具体研究方向补充筛选条件(如疾病类型或技术方法)。
The CPA2 (Carboxypeptidase A2) antibody is a tool used to detect and study CPA2. a zinc-dependent exopeptidase primarily synthesized in the pancreas as an inactive zymogen (proCPA2). CPA2 plays a critical role in protein digestion by cleaving hydrophobic C-terminal amino acids from dietary peptides, working alongside CPA1 but with distinct substrate preferences. While CPA1 is abundant in the pancreas, CPA2 expression is lower and may vary across tissues or pathological conditions.
CPA2 antibodies are essential for investigating pancreatic function, digestive disorders, and diseases like pancreatitis or pancreatic cancer. They enable localization and quantification of CPA2 via techniques such as immunohistochemistry, Western blotting, and ELISA. Research suggests CPA2 may serve as a biomarker in certain cancers, where its aberrant expression correlates with tumor progression.
However, challenges exist due to structural similarities between CPA2 and other carboxypeptidases (e.g., CPA1. CPA3), necessitating rigorous validation of antibody specificity using knockout controls or recombinant proteins. Commercial CPA2 antibodies are typically raised against peptide epitopes or full-length proteins, with applications spanning basic research and diagnostic development. Recent studies also explore CPA2's potential roles beyond digestion, including peptide hormone processing and inflammatory pathways.
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