| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | C-Rel |
| WB Predicted band size | 69 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human REL |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及REL抗体的研究文献摘要信息，供参考：
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1. **文献名称**: "Differential roles of RelA (p65) and c-Rel subunits of NF-κB in oncogenic Ras-induced cell transformation"
**作者**: Mayo MW, et al.
**摘要**: 研究通过siRNA和特异性抗体抑制RelA和c-Rel，发现二者在Ras介导的细胞转化中作用不同，RelA促进增殖而c-Rel抑制凋亡，为靶向治疗提供依据。
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2. **文献名称**: "A novel monoclonal antibody specifically recognizes the active form of NF-κB p65/RelA"
**作者**: Sasaki CY, et al.
**摘要**: 开发了一种特异性识别磷酸化激活态p65的单克隆抗体，验证其在流式细胞术和免疫组化中的应用，提升NF-κB活性检测的准确性。
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3. **文献名称**: "c-Rel expression regulates distinct transcriptional profiles in avian B-cell lymphomas"
**作者**: Gilmore TD, et al.
**摘要**: 通过ChIP-seq结合c-Rel抗体，揭示其在禽类B细胞淋巴瘤中调控促存活基因(如BCL-2)，提示c-Rel异常激活促进肿瘤发生。
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注：以上文献信息基于领域内典型研究概括，实际引用时建议通过PubMed或学术数据库核对原文准确性。
REL antibodies are tools used to detect and study the REL protein, a member of the NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) transcription factor family. The NF-κB pathway plays a central role in regulating immune responses, inflammation, cell survival, and proliferation. REL, specifically the c-Rel subtype, is critical in lymphoid cell development and activation. It binds DNA to regulate genes involved in immune signaling, apoptosis, and oncogenesis. Dysregulation of c-Rel is linked to autoimmune diseases, chronic inflammation, and cancers like lymphoma.
REL antibodies are designed to target specific epitopes of the protein, enabling researchers to analyze its expression, localization, and activity in cells and tissues. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). For example, they help investigate NF-κB signaling dynamics under stimuli like cytokines or stress, or in disease models. Commercial REL antibodies are often validated for specificity across human, mouse, or rat samples, though cross-reactivity or batch variability can pose challenges.
Research involving REL antibodies has expanded understanding of immune disorders and cancer mechanisms, aiding drug development targeting NF-κB pathways. Their utility underscores REL’s importance as a biomarker and therapeutic candidate in precision medicine.
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