Rabbit Polyclonal CRISP3 Antibody

The Cysteine-Rich Secretory Protein 3 (CRISP3) is a member of the CRISP family, which is characterized by conserved cysteine-rich domains and roles in cell adhesion, immune response, and reproduction. CRISP3 is primarily expressed in secretory tissues, including salivary glands, the prostate, and neutrophils, and is secreted into bodily fluids such as saliva, semen, and seminal plasma. Its proposed functions range from modulating ion channels to regulating innate immunity and sperm-egg fusion. CRISP3 antibodies are essential tools for studying its expression, localization, and biological roles. Research has linked CRISP3 overexpression to pathologies like prostate cancer, where it may promote tumor progression, and pancreatitis, where it contributes to inflammation. Conversely, reduced CRISP3 levels are associated with male infertility. Antibodies targeting CRISP3 enable detection via techniques like immunohistochemistry, Western blotting, and ELISA, aiding in both basic research and clinical diagnostics. Recent studies also explore its potential as a biomarker or therapeutic target. However, challenges remain in understanding its precise molecular mechanisms and tissue-specific functions, necessitating further investigation using well-validated CRISP3-specific antibodies.