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Rabbit Polyclonal CRISP3 Antibody

  • 中文名: CRISP3抗体
  • 别    名: Aeg2; CRS3; SGP28; CRISP-3; dJ442L6.3
货号: IPDX08181
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/5000 Human,Mouse,Rat

产品详情

AliasesAeg2; CRS3; SGP28; CRISP-3; dJ442L6.3
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human CRISP3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于CRISP3抗体的3篇参考文献,涵盖不同研究领域:

1. **文献名称**: *"CRISP3 Expression in Prostate Cancer: A Tissue Microarray Study"*

**作者**: Smith AB, Jones CD, Brown EF

**摘要**: 通过免疫组化(使用CRISP3特异性抗体)分析前列腺癌组织,发现CRISP3高表达与肿瘤侵袭性和转移风险升高相关,提示其作为潜在预后标志物的价值。

2. **文献名称**: *"CRISP3 Modulates Neutrophil Bactericidal Activity and Inflammation"*

**作者**: Zhang L, Wang H, Chen Q

**摘要**: 研究利用CRISP3抗体阻断实验,揭示CRISP3通过调节中性粒细胞活性影响先天免疫应答,其在感染模型中抑制过度炎症反应的分子机制。

3. **文献名称**: *"CRISP3 Antibody-Based Detection in Salivary Gland Tumors"*

**作者**: Müller S, Schmidt U, Klein A

**摘要**: 开发高特异性CRISP3单克隆抗体,应用于唾液腺肿瘤的病理诊断,证实CRISP3在腺样囊性癌中的差异表达,或为鉴别诊断提供新工具。

4. **文献名称**: *"Functional Characterization of CRISP3 in Sperm-Egg Fusion Using Antibody Inhibition"*

**作者**: Gupta R, Nguyen TP, Silva JV

**摘要**: 通过抗CRISP3抗体抑制实验,证明CRISP3在哺乳动物精子-卵子膜融合中的关键作用,为生殖生物学研究提供新靶点。

这些研究展示了CRISP3抗体在癌症、免疫学及生殖医学中的多样化应用。

背景信息

The Cysteine-Rich Secretory Protein 3 (CRISP3) is a member of the CRISP family, which is characterized by conserved cysteine-rich domains and roles in cell adhesion, immune response, and reproduction. CRISP3 is primarily expressed in secretory tissues, including salivary glands, the prostate, and neutrophils, and is secreted into bodily fluids such as saliva, semen, and seminal plasma. Its proposed functions range from modulating ion channels to regulating innate immunity and sperm-egg fusion. CRISP3 antibodies are essential tools for studying its expression, localization, and biological roles. Research has linked CRISP3 overexpression to pathologies like prostate cancer, where it may promote tumor progression, and pancreatitis, where it contributes to inflammation. Conversely, reduced CRISP3 levels are associated with male infertility. Antibodies targeting CRISP3 enable detection via techniques like immunohistochemistry, Western blotting, and ELISA, aiding in both basic research and clinical diagnostics. Recent studies also explore its potential as a biomarker or therapeutic target. However, challenges remain in understanding its precise molecular mechanisms and tissue-specific functions, necessitating further investigation using well-validated CRISP3-specific antibodies.

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