关键信息
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基因名
IFNAR1
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简介
IFNAR1, one of the subunit of IFN-α/β receptor, is a type I IFN receptor. IFNAR1 forms the heterodimeric receptor with IFNAR2. IFNAR1 mediates IFN-induced STAT signaling by interacting with tyrosine kinase 2 (Tyk2)[1][2]. Upon activation by these IFNs, IFNAR1 and IFNAR2 undergo a conformational change to promote a cascade of downstream signaling events, including the phosphorylation of Tyk2 and JAK1, STAT1 and STAT2[3]. IFNAR1 Protein, Human (HEK293, Fc) is a recombinant human IFNAR1 (K28-K436) with C-terminal hFc tag, which is produced in HEK293 cells.
- 应用
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别名
Interferon alpha/beta receptor 1; IFN-alpha/beta R1; Ifnar1; Ifar; Ifnar
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种属
Human
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P17181-1
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表达区间
K28-K436
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蛋白长度
Extracellular Domain
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分子量
100-120 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
IFNAR1, the Interferon-Alpha/Beta Receptor 1, is a critical component of the immune response and plays a pivotal role in the signaling pathways activated by type I interferons (IFN-I). These cytokines are vital for the host defense against viral infections and in modulating immune responses. Research into IFNAR1 recombinant proteins has gained momentum due to their potential applications in therapeutic interventions for viral diseases, autoimmune disorders, and cancer. Understanding the molecular mechanisms of IFNAR1 signaling helps elucidate how cells respond to viral pathogens and contribute to establishing an antiviral state. Additionally, IFNAR1 has been implicated in various diseases, making it a target for drug development. Recombinant IFNAR1 proteins can also serve as valuable tools for studying receptor interactions and signaling pathways, potentially leading to the identification of novel therapeutic strategies. Moreover, as the demand for effective biotherapeutics rises, characterizing and optimizing the production of IFNAR1 recombinant proteins is crucial for advancing research and clinical applications in immunology.
