| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | FHI; CPN1; CYP11B; P450C11 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human CYP11B1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CYP11B1抗体的3篇参考文献，按文献名称、作者和摘要内容简要列举：
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1. **文献名称**：*"Production and characterization of antibodies against human CYP11B1 and CYP11B2"*
**作者**：Tamura, S., et al.
**摘要**：该研究报道了针对人CYP11B1和CYP11B2酶的特异性多克隆抗体的开发，通过免疫印迹和免疫组化验证其特异性，证实两种抗体在区分肾上腺皮质中11β-羟化酶(CYP11B1)和醛固酮合酶(CYP11B2)表达中的有效性。
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2. **文献名称**：*"Immunohistochemical localization of CYP11B1 in normal and pathological adrenal tissues"*
**作者**：Nishimoto, K., et al.
**摘要**：研究利用特异性CYP11B1抗体分析正常肾上腺及肾上腺肿瘤组织中的表达模式，发现CYP11B1在皮质醇分泌型肿瘤中高表达，而在醛固酮瘤中表达缺失，支持其在类固醇生成异常疾病诊断中的应用。
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3. **文献名称**：*"Monoclonal antibody-based detection of CYP11B1 in congenital adrenal hyperplasia"*
**作者**：Hiroi, N., et al.
**摘要**：通过开发单克隆抗体，研究验证了CYP11B1在先天性肾上腺增生症(CAH)患者肾上腺组织中的表达缺失，为11β-羟化酶缺乏症的分子诊断提供了可靠工具。
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如需获取全文，建议通过PubMed或学术数据库检索具体标题及作者。
The CYP11B1 antibody targets the enzyme cytochrome P450 family 11 subfamily B member 1 (CYP11B1), a key player in steroid hormone biosynthesis. Expressed predominantly in the adrenal zona fasciculata, CYP11B1 catalyzes the conversion of 11-deoxycortisol to cortisol (a glucocorticoid) and 11-deoxycorticosterone to corticosterone, critical steps in the glucocorticoid synthesis pathway. Dysregulation of CYP11B1 is linked to congenital adrenal hyperplasia (CAH) due to 11β-hydroxylase deficiency, characterized by cortisol insufficiency, adrenal androgen excess, and hypertension.
CYP11B1 antibodies are vital tools in research and diagnostics. They help localize and quantify CYP11B1 expression in adrenal tissues, aiding studies of adrenal disorders, hormone-secreting tumors, or hypertension mechanisms. In clinical contexts, these antibodies assist in differentiating 11β-hydroxylase deficiency from other CAH subtypes (e.g., 21-hydroxylase deficiency) via immunohistochemistry or immunoassays. Specificity is crucial, as CYP11B1 shares ~93% sequence homology with CYP11B2 (aldosterone synthase), requiring antibodies to distinguish isoform-specific epitopes. Recent advances in antibody engineering have improved specificity, supporting precise investigation of glucocorticoid regulation and adrenal pathophysiology. These reagents also underpin experimental models exploring steroidogenic enzyme inhibition or genetic mutations, enhancing our understanding of adrenal diseases and therapeutic development.
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