| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | MTVR1 |
| WB Predicted band size | 20 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human FAM89B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FAM89B抗体的3篇参考文献示例(内容为模拟，实际文献需通过学术数据库查询)：
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1. **文献名称**：*FAM89B regulates mitochondrial metabolism in glioblastoma through antibody-based proteomic analysis*
**作者**：Smith A, et al.
**摘要**：本研究利用FAM89B特异性抗体，通过免疫沉淀和质谱分析，发现FAM89B在胶质母细胞瘤线粒体能量代谢中的调控作用，为肿瘤治疗提供潜在靶点。
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2. **文献名称**：*Characterization of FAM89B antibody specificity in neurodegenerative disease models*
**作者**：Chen L, et al.
**摘要**：通过Western blot和免疫荧光验证FAM89B抗体的特异性，发现FAM89B在阿尔茨海默病模型中表达异常，可能与神经元线粒体功能障碍相关。
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3. **文献名称**：*FAM89B knockout mice reveal immune-related functions via antibody-mediated tissue profiling*
**作者**：Wang Y, et al.
**摘要**：采用FAM89B抗体对基因敲除小鼠进行组织染色，发现FAM89B缺失导致免疫细胞(如巨噬细胞)炎症因子分泌异常，提示其在先天免疫中的潜在作用。
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**说明**：以上为示例性内容，实际文献需通过PubMed、Google Scholar等平台检索关键词“FAM89B antibody”或“FAM89B AND immunohistochemistry/WB”获取。若研究较少，可扩大至相关功能研究(如线粒体、疾病机制)，并关注方法学中是否提及抗体使用。
The FAM89B antibody targets the FAM89B protein, encoded by the FAM89B gene (Family With Sequence Similarity 89 Member B), which is conserved across vertebrates but remains relatively understudied. FAM89B is a cytoplasmic protein implicated in immune regulation and cellular metabolism. Early studies suggest its potential involvement in modulating inflammatory responses, possibly through interactions with immune signaling pathways like NF-κB or MAPK. FAM89B has also been linked to metabolic processes, with altered expression observed in conditions such as obesity and type 2 diabetes.
Antibodies against FAM89B are primarily used as research tools to investigate its expression patterns, subcellular localization, and functional roles. They enable techniques like Western blotting, immunofluorescence, and immunohistochemistry, aiding in protein detection across tissues and cell lines. Some studies employ FAM89B antibodies to explore its potential as a biomarker or therapeutic target in diseases like cancer, where dysregulated FAM89B expression has been reported.
Commercial FAM89B antibodies are typically polyclonal or monoclonal, raised in hosts like rabbits or mice, and require validation via knockout controls or siRNA-mediated silencing to confirm specificity. Despite limited clinical data, ongoing research aims to clarify FAM89B's mechanistic contributions to immunity and metabolism, positioning it as a protein of growing interest in biomedical contexts.
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