Rabbit Polyclonal GCM1 Antibody

The GCM1 antibody is a crucial tool in studying the GCM1 (Glial Cells Missing 1) protein, a transcription factor belonging to the GCM family. Initially identified in *Drosophila* for its role in glial cell development, mammalian GCM1 is primarily expressed in placental tissues and plays a pivotal role in trophoblast differentiation, syncytiotrophoblast formation, and placental vascularization. It regulates genes involved in cell fusion and hormone production, essential for maintaining pregnancy. Dysregulation of GCM1 is linked to placental pathologies, such as preeclampsia and intrauterine growth restriction, as well as certain cancers, including choriocarcinoma. The GCM1 antibody enables researchers to detect and quantify GCM1 expression via techniques like Western blot, immunohistochemistry, and immunofluorescence. It is widely used to investigate placental development, tumor biology, and molecular mechanisms underlying GCM1-associated diseases. Commercially available antibodies are typically raised in rabbits or mice, targeting specific epitopes within the N-terminal or C-terminal regions. Validation methods, such as knockout cell lines or siRNA knockdown, ensure specificity. Beyond research, GCM1 has potential clinical applications as a diagnostic or prognostic biomarker, underscoring the antibody's importance in both basic and translational studies.