| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | GGT; GTG; CD224; GGT 1; D22S672; D22S732 |
| WB Predicted band size | 61 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | Fusion protein of human GGT1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GGT1抗体的模拟参考文献(内容为示例，非真实文献)：
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1. **文献名称**: "GGT1 as a Biomarker in Hepatocellular Carcinoma: Development of a Novel Monoclonal Antibody for Diagnostic Use"
**作者**: Li et al.
**摘要**: 研究开发了一种高特异性抗GGT1单克隆抗体，验证了其在肝癌组织中的过表达，证明其可作为血清和组织病理学诊断的潜在工具。
2. **文献名称**: "Targeted Drug Delivery Using GGT1 Antibody-Conjugated Nanoparticles in Pancreatic Cancer"
**作者**: Smith & Kumar
**摘要**: 利用GGT1抗体修饰的纳米颗粒靶向递送化疗药物，结果显示其在胰腺癌小鼠模型中显著提高肿瘤部位药物浓度并减少副作用。
3. **文献名称**: "Autoantibodies Against GGT1 in Rheumatoid Arthritis: Correlation with Disease Activity"
**作者**: Tanaka et al.
**摘要**: 发现类风湿性关节炎患者血清中存在抗GGT1自身抗体，其水平与疾病活动度正相关，提示其在自身免疫病理机制中的潜在作用。
4. **文献名称**: "GGT1 Inhibition via Neutralizing Antibodies Attenuates Oxidative Stress in Alzheimer's Disease Models"
**作者**: Rodriguez et al.
**摘要**: 通过中和GGT1抗体抑制酶活性，减少阿尔茨海默病细胞模型中的氧化损伤，为神经退行性疾病治疗提供新策略。
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注：以上文献为虚拟示例，实际研究中请通过PubMed、Google Scholar等平台查询真实文献。
GGT1 (gamma-glutamyltransferase 1) antibodies are immunological tools used to detect and study the GGT1 enzyme, a cell membrane-associated protein involved in glutathione metabolism and amino acid transport. GGT1 catalyzes the cleavage of extracellular glutathione, facilitating cysteine recycling and maintaining intracellular redox balance. It is highly expressed in tissues with secretory or absorptive functions, such as the liver, kidney, and pancreas, and its dysregulation has been linked to oxidative stress-related pathologies, including liver disease, cardiovascular disorders, and cancer.
GGT1 antibodies are primarily employed in research to investigate the enzyme's expression, localization, and role in disease mechanisms. In oncology, elevated GGT1 levels are associated with tumor progression, drug resistance, and poor prognosis, making these antibodies valuable in cancer biomarker studies. They are also used in diagnostic settings to assess hepatic or biliary dysfunction.
Available as monoclonal or polyclonal forms, GGT1 antibodies are optimized for techniques like Western blotting, immunohistochemistry, and ELISA. Validation includes specificity checks using knockout controls or recombinant proteins. Challenges in application may arise from cross-reactivity with other GGT isoforms or tissue-specific post-translational modifications. Recent studies explore GGT1's potential as a therapeutic target, driving demand for high-affinity antibodies in preclinical drug development.
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