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Rabbit Polyclonal GYPC Antibody

  • 中文名: GYPC抗体
  • 别    名: GE; GPC; GPD; GYPD; CD236; PAS-2; CD236R; PAS-2
货号: IPDX08380
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/300 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/10000 Human,Mouse,Rat

产品详情

AliasesGE; GPC; GPD; GYPD; CD236; PAS-2; CD236R; PAS-2
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human GYPC
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于GYPC抗体的3篇参考文献示例(内容基于公开文献概括,非真实引用,仅供参考):

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1. **文献名称**:*Glycophorin C (GYPC) mutations and their role in hereditary elliptocytosis*

**作者**:Reid ME, et al.

**摘要**:研究GYPC基因突变与遗传性椭圆红细胞增多症的关系,通过特异性抗体检测红细胞膜GYPC蛋白异常表达,揭示其与细胞骨架稳定性缺陷的关联。

2. **文献名称**:*Monoclonal antibodies against GYPC for malaria invasion studies*

**作者**:Mayer DC, et al.

**摘要**:开发针对GYPC的单克隆抗体,用于探究疟原虫(如恶性疟原虫)入侵红细胞时与GYPC的相互作用,证实GYPC是疟疾感染的关键宿主受体。

3. **文献名称**:*Anti-GYPC autoantibodies in autoimmune hemolytic anemia*

**作者**:Tournamille C, et al.

**摘要**:报道自身免疫性溶血性贫血患者体内抗GYPC抗体与红细胞破坏的关联,提出此类抗体可能作为罕见亚型的生物标志物。

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注:以上文献信息为示例,实际引用需查询PubMed、Google Scholar等数据库获取真实文献。

背景信息

GYPC antibody targets glycophorin C (GYPC), a sialoglycoprotein expressed on the erythrocyte membrane. As a member of the glycophorin family, GYPC plays a critical role in maintaining membrane structural integrity by linking the cytoskeleton to the lipid bilayer via protein 4.1R and p55. It carries the Gerbich (Ge) blood group antigens, with variants influencing susceptibility to Plasmodium falciparum malaria and associations with hereditary elliptocytosis. GYPC antibodies are clinically significant in transfusion medicine and hematology. Naturally occurring anti-Ge antibodies may cause hemolytic transfusion reactions or hemolytic disease of the fetus/newborn. Autoantibodies against GYPC are occasionally observed in autoimmune hemolytic anemia. In research, GYPC antibodies are utilized to study erythrocyte membrane disorders, malaria invasion mechanisms, and antigenic variations. Commercial GYPC antibodies typically recognize extracellular epitopes, aiding in blood group typing and biochemical characterization. Recent studies also explore GYPC's potential as a biomarker in certain cancers, expanding its investigative applications beyond hematology.

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