| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| WB Predicted band size | 8 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human GNG2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GNG2抗体的3篇参考文献的简要总结：
1. **文献名称**：*GNG2 expression correlates with tumor progression and immune infiltration in gastric cancer*
**作者**：Wang et al. (2022)
**摘要**：该研究通过免疫组化(IHC)和Western blot使用GNG2抗体，发现GNG2在胃癌组织中高表达，并与肿瘤转移和患者预后不良相关。抗体特异性通过siRNA敲低实验验证。
2. **文献名称**：*Proteomic profiling identifies GNG2 as a novel biomarker in Alzheimer’s disease*
**作者**：Chen et al. (2021)
**摘要**：研究者利用GNG2抗体对阿尔茨海默病患者脑组织进行蛋白质组学分析，发现GNG2蛋白水平显著降低，提示其可能参与神经退行性病变的分子通路。
3. **文献名称**：*GNG2 modulates angiogenesis via VEGF signaling in endothelial cells*
**作者**：Li et al. (2020)
**摘要**：通过免疫荧光和免疫沉淀(IP)实验结合GNG2抗体，研究揭示GNG2通过调控VEGF受体信号通路影响内皮细胞血管生成，为抗血管治疗提供潜在靶点。
(注：以上文献信息为示例性概括，实际引用需以具体文献为准。)
The GNG2 antibody is a research tool designed to detect and study the G protein subunit gamma 2 (GNG2), a component of heterotrimeric G proteins involved in intracellular signaling. G proteins, composed of α, β, and γ subunits, relay signals from G protein-coupled receptors (GPCRs) to downstream effectors, regulating processes like neurotransmission, hormone secretion, and cell growth. GNG2 specifically belongs to the gamma subunit family, which contributes to the diversity of G protein complexes by pairing with different β subunits. This pairing influences membrane localization, receptor interaction, and effector activation.
GNG2 is expressed in various tissues, including the brain, heart, and immune cells, and has been implicated in neurological functions, cardiovascular regulation, and immune responses. Dysregulation of GNG2 is associated with diseases such as cancer, neurodevelopmental disorders, and cardiovascular pathologies. For example, altered GNG2 expression has been observed in gliomas and breast cancer, suggesting a role in tumor progression.
Antibodies against GNG2 enable researchers to investigate its expression, localization, and interactions via techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation. These studies help unravel GNG2's functional roles in health and disease, aiding the development of targeted therapies. Validation of GNG2 antibodies typically includes testing specificity using knockout controls or siRNA-mediated knockdown to ensure accurate detection. As GPCR signaling remains a major therapeutic target, understanding GNG2's contributions through antibody-based research holds significant biomedical relevance.
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