| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | MG44; KMT1A; SUV39H; H3-K9-HMTase 1 |
| WB Predicted band size | 48 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human SUV39H1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SUV39H1抗体的3篇参考文献，包含文献名称、作者及摘要内容的简要概括：
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1. **文献名称**：*Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain*
**作者**：Bannister, A.J., Zegerman, P., Partridge, J.F., et al.
**摘要**：本研究通过免疫荧光和染色质免疫沉淀(ChIP)实验，使用SUV39H1抗体验证了HP1蛋白通过其chromo结构域特异性识别H3K9me3修饰的机制，揭示了SUV39H1在异染色质形成中的核心作用。
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2. **文献名称**：*Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability*
**作者**：Peters, A.H., O’Carroll, D., Scherthan, H., et al.
**摘要**：通过基因敲除小鼠模型，结合SUV39H1抗体的Western blot和免疫组化分析，发现Suv39h1/2双敲除导致H3K9me3水平显著降低，引发染色体不稳定性和发育缺陷，证明其在基因组完整性中的关键功能。
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3. **文献名称**：*Regulation of Suv39h1 histone methyltransferase by phosphorylation*
**作者**：Rea, S., Eisenhaber, F., O’Carroll, D., et al.
**摘要**：利用SUV39H1特异性抗体进行免疫沉淀和激酶实验，揭示了SUV39H1的酶活性受磷酸化调控，并发现其与细胞周期进程的关联，为表观遗传修饰的动态调控提供了机制解释。
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这些文献涵盖了SUV39H1抗体在染色质修饰、基因组稳定性及酶活性调控研究中的关键应用。如需更多文献或特定研究方向，可进一步补充说明。
The SUV39H1 antibody is a crucial tool in epigenetics research, targeting the Suppressor of Variegation 3-9 Homolog 1 protein, a conserved histone methyltransferase. SUV39H1 catalyzes trimethylation of histone H3 at lysine 9 (H3K9me3), a hallmark of heterochromatin formation and gene silencing. First identified in *Drosophila* as a regulator of position-effect variegation, mammalian SUV39H1 plays key roles in chromatin organization, X-chromosome inactivation, and genomic stability.
This antibody is widely used to study SUV39H1's function in cell differentiation, cancer biology, and aging. It enables detection of protein expression levels, subcellular localization (primarily nucleus), and interaction partners through techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP). Researchers employ it to investigate SUV39H1's dual role in tumor suppression (via heterochromatin maintenance) and potential oncogenic activity (through aberrant gene silencing).
Commercial variants include monoclonal and polyclonal formats, with validation typically performed in knockout cell lines. Proper controls are essential due to cross-reactivity risks with related methyltransferases. Recent studies highlight its relevance in viral defense mechanisms, stem cell pluripotency, and metabolic reprogramming, making this antibody vital for dissecting epigenetic regulation in health and disease.
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