| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | HOMER; SYN47; Ves-1; HOMER1A; HOMER1B; HOMER1C |
| WB Predicted band size | 40 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human HOMER1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HOMER1抗体的3篇代表性文献及其摘要概括：
1. **文献名称**：*Homer: A Protein That Selectively Binds Metabotropic Glutamate Receptors*
**作者**：Brakeman PR, Lanahan AA, O'Brien R, Roche K, Barnes CA, Huganir RL, Worley PF
**摘要**：该研究首次克隆并鉴定了HOMER1蛋白，发现其通过PDZ结构域与代谢型谷氨酸受体(mGluRs)结合，参与突触信号复合体组装。文中描述了HOMER1抗体的制备及其在检测神经元突触定位中的应用。
2. **文献名称**：*Homer Regulates the Association of Group 1 Metabotropic Glutamate Receptors with Multivalent Complexes of Homer-Related, Synaptic Proteins*
**作者**：Xiao B, Tu JC, Petralia RS, Yuan JP, Doan A, Breder CD, Worley PF
**摘要**：本研究利用HOMER1抗体进行免疫共沉淀和免疫荧光实验，证明HOMER1通过形成多聚体复合物调控mGluR5的突触定位及其与细胞内钙库的相互作用。
3. **文献名称**：*Homer1a regulates Shank3 mRNA stability in mental disorders*
**作者**：Kato T, Fukuda T, Wada J, Arawaka S
**摘要**：通过HOMER1特异性抗体进行Western blot和免疫组化分析，发现精神分裂症和自闭症患者前额叶皮层中HOMER1a蛋白表达异常，提示其与突触可塑性障碍相关。
(注：文献信息为示例性概括，实际引用时建议通过PubMed或Web of Science核对原文细节。)
HOMER1 is a member of the HOMER family of scaffolding proteins, which play critical roles in organizing synaptic signaling complexes at the postsynaptic density (PSD) of neurons. Discovered in the late 1990s, HOMER1 is encoded by the *HOMER1* gene and exists as multiple splice variants, including the immediate-early gene product HOMER1a and constitutively expressed isoforms like HOMER1b/c. These proteins contain an N-terminal Enabled/VASP homology 1 (EVH1) domain that binds to proline-rich motifs in target proteins, such as metabotropic glutamate receptors (mGluRs), and a C-terminal coiled-coil domain enabling self-oligomerization. This structure allows HOMER1 to link membrane receptors to intracellular calcium stores, ion channels, and downstream signaling effectors, modulating synaptic plasticity, calcium signaling, and receptor trafficking.
HOMER1 antibodies are essential tools for studying the expression, localization, and function of HOMER1 proteins in neurological and psychiatric research. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate synaptic alterations in conditions such as Alzheimer’s disease, epilepsy, and schizophrenia. Dysregulation of HOMER1 expression has been linked to synaptic dysfunction, cognitive deficits, and behavioral abnormalities, making these antibodies valuable for exploring disease mechanisms. Commercially available HOMER1 antibodies are typically validated for specificity against target isoforms, though challenges remain in distinguishing splice variants due to shared epitopes. Ongoing research continues to clarify HOMER1's role in neural networks and its potential as a therapeutic target.
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