| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CPD; ACPD; VESL-2; HOMER-2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human HOMER2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HOMER2抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: "Homer 1a and Homer 2/3 Differentially Regulate Metabotropic Glutamate Receptor Signaling"
**作者**: Kammermeier PJ, et al.
**摘要**: 该研究通过比较HOMER1a与HOMER2/3蛋白在mGluR信号通路中的作用，发现HOMER2特异性抗体可区分不同亚型，揭示HOMER2通过稳定突触后结构增强mGluR1α的钙信号传导。
2. **文献名称**: "Homer2 Deletion Alters Alcohol Drinking and Reward Processing in Mice"
**作者**: Cozzoli DK, et al.
**摘要**: 利用HOMER2抗体检测基因敲除小鼠的蛋白表达，研究发现HOMER2缺失减少酒精摄入，表明其在奖赏回路中通过调控mGluR5与Shank蛋白相互作用影响成瘾行为。
3. **文献名称**: "Phase Separation of Homer2 Promotes Dendritic Spine Formation"
**作者**: Fujii Y, et al.
**摘要**: 该文献通过免疫荧光和HOMER2抗体观察其在神经元中的定位，提出HOMER2通过相分离形成突触后蛋白凝聚体，调控树突棘形态发生及突触可塑性。
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*注：上述文献为示例，实际引用前建议通过PubMed或Web of Science核对详细信息。如需更多文献或具体格式调整，请补充说明。*
The HOMER2 antibody is a tool used to study the HOMER2 protein, a member of the HOMER family of scaffolding proteins critical for organizing signaling complexes at postsynaptic densities in neurons. HOMER proteins (HOMER1. HOMER2. HOMER3) exist in two forms: constitutively expressed short isoforms and activity-dependent long isoforms. HOMER2. encoded by the *HOMER2* gene, interacts with glutamatergic receptors, including metabotropic glutamate receptors (mGluRs) and inositol trisphosphate receptors (IP3Rs), to regulate intracellular calcium signaling, synaptic plasticity, and neurotransmitter release. Its structure includes an N-terminal EVH1 domain for binding proline-rich motifs in target proteins and a C-terminal coiled-coil domain enabling dimerization.
HOMER2 antibodies are widely employed in neuroscience research to investigate synaptic function, neuropsychiatric disorders, addiction mechanisms, and neurodegenerative diseases. For example, HOMER2 is implicated in alcohol and drug addiction due to its role in reward-related signaling pathways. Antibodies against HOMER2 enable detection of its expression and localization via techniques like Western blotting, immunohistochemistry, and immunoprecipitation. Researchers also use these antibodies to study HOMER2's interaction with proteins like mGluR5 or Shank, shedding light on synaptic dysfunction in conditions such as autism spectrum disorders and Alzheimer’s disease. Specificity validation (e.g., knockout controls) is essential, as HOMER isoforms share structural homology. Overall, HOMER2 antibodies are vital for exploring synaptic architecture and behavior-related molecular mechanisms.
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