| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | DJ-2; DjA1; HDJ2; HSDJ; HSJ2; HSPF4; NEDD7; hDJ-2 |
| WB Predicted band size | 45 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human DNAJA1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DNAJA1抗体的3篇代表性文献的简要概括(注：以下内容为示例，非真实文献)：
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1. **文献名称**：DNAJA1 overexpression promotes colorectal cancer metastasis via HSP90-mediated stabilization of β-catenin
**作者**：Li X, et al.
**摘要**：该研究利用DNAJA1抗体检测其在结直肠癌组织中的表达水平，发现DNAJA1高表达与患者预后不良相关。机制研究表明，DNAJA1通过结合HSP90增强β-catenin蛋白稳定性，激活Wnt信号通路，促进肿瘤侵袭转移。
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2. **文献名称**：DNAJA1 modulates α-synuclein aggregation in Parkinson’s disease models
**作者**：Smith J, et al.
**摘要**：通过免疫沉淀(使用DNAJA1抗体)和细胞模型，研究发现DNAJA1与α-synuclein相互作用，抑制其异常聚集。敲低DNAJA1会加剧多巴胺能神经元死亡，提示其在帕金森病中具有神经保护作用。
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3. **文献名称**：Prognostic significance of DNAJA1 in hepatocellular carcinoma: A tissue microarray study
**作者**：Wang Y, et al.
**摘要**：基于组织芯片和DNAJA1抗体的免疫组化分析，研究发现DNAJA1在肝细胞癌中高表达，并与肿瘤分级、血管浸润显著相关。多变量分析表明，DNAJA1是独立的预后标志物，可能作为治疗靶点。
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如需真实文献，建议通过PubMed或Google Scholar搜索关键词“DNAJA1 antibody”、“DNAJA1 biomarker”或“DNAJA1 function”获取最新研究。
DNAJA1 antibody is a research tool targeting DNAJA1. a member of the Hsp40 (heat shock protein 40) family. Also known as Hdj2 or HdjA, DNAJA1 functions as a co-chaperone for Hsp70 proteins, assisting in protein folding, stress response, and cellular homeostasis. It contains a conserved J-domain that interacts with Hsp70 and additional domains (G/F and C-terminal regions) involved in substrate binding. DNAJA1 is implicated in various pathologies, including cancer, where it exhibits dual roles—acting as an oncogene in breast and liver cancers by promoting cell proliferation, while showing tumor-suppressive effects in colorectal cancer. It also participates in neurodegenerative diseases like Parkinson's by modulating protein aggregation.
The antibody enables detection and quantification of DNAJA1 in techniques such as Western blotting, immunoprecipitation, and immunohistochemistry. Its applications extend to studying DNAJA1's interactions with client proteins (e.g., EGFR, PTEN) and regulatory mechanisms under stress conditions. Commercial DNAJA1 antibodies are typically developed in rabbit or mouse hosts, validated for specificity across human and common model organisms. Recent studies emphasize its role in cancer metabolism, drug resistance, and viral infection pathways, making it valuable for both basic research and therapeutic target exploration. Proper validation using knockout controls remains essential due to potential cross-reactivity with other Hsp40 family members.
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