| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | PRAP; SDR37C1 |
| WB Predicted band size | 38 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human HSD17B7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及HSD17B7抗体的参考文献概览：
1. **文献名称**: "HSD17B7: A key enzyme in cholesterol biosynthesis and its expression regulation"
**作者**: Smith A, et al.
**摘要**: 研究利用HSD17B7特异性抗体，通过Western blot和免疫荧光技术，揭示了该酶在胆固醇合成途径中的核心作用，并发现其表达受SREBP通路调控。
2. **文献名称**: "Immunohistochemical localization of HSD17B7 in human ovarian tumors"
**作者**: Chen L, et al.
**摘要**: 通过HSD17B7抗体进行组织染色，发现该酶在卵巢癌组织中高表达，提示其可能作为肿瘤代谢异常的潜在生物标志物。
3. **文献名称**: "Functional characterization of HSD17B7 knockout mice using antibody-based assays"
**作者**: Tanaka K, et al.
**摘要**: 研究采用HSD17B7抗体对基因敲除小鼠模型进行分析，证实该酶缺失导致胆固醇前体积累，并引发胚胎发育异常，阐明其生理功能的重要性。
注：以上文献信息为示例性内容，实际文献需通过PubMed/Google Scholar检索确认。若需具体文献，可提供论文DOI或PMID进一步查询。
The HSD17B7 antibody targets the enzyme 17β-hydroxysteroid dehydrogenase type 7 (HSD17B7), a member of the 17β-HSD family involved in steroid metabolism. HSD17B7 primarily catalyzes the conversion of estrone to estradiol and androstenedione to testosterone, playing a dual role in estrogen and androgen biosynthesis. It also participates in cholesterol synthesis by reducing ketosterols to intermediates in the Bloch pathway. This enzyme is expressed in steroidogenic tissues (e.g., ovaries, testes) and non-steroidogenic organs (e.g., liver, brain), linking it to reproductive health, lipid homeostasis, and neurosteroid regulation.
HSD17B7 antibodies are essential tools for studying its expression, localization, and function in cellular models and tissues. They enable detection via Western blotting, immunohistochemistry, and immunofluorescence, aiding research on HSD17B7's role in diseases such as hormone-dependent cancers (e.g., breast, prostate), polycystic ovary syndrome (PCOS), and metabolic disorders. Dysregulation of HSD17B7 has been implicated in tumor progression due to altered steroid hormone levels, while its cholesterol-related activity may influence neurodegenerative conditions like Alzheimer’s disease. These antibodies also support drug development targeting HSD17B7 to modulate steroid pathways or cholesterol synthesis. Validation of antibody specificity remains critical due to structural similarities among 17β-HSD isoforms.
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