| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | KE6; FABG; HKE6; FABGL; RING2; H2-KE6; SDR30C1; D6S2245E; dJ1033B10.9 |
| WB Predicted band size | 27 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human HSD17B8 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HSD17B8抗体的3篇参考文献示例(文献内容为模拟概括，仅供参考)：
1. **"Characterization of HSD17B8 antibody specificity in human tissues"**
*Author: Smith A, et al.*
摘要：本研究验证了一种多克隆HSD17B8抗体的特异性，通过Western blot和免疫组化技术证明其在人肝、卵巢及乳腺癌细胞中能特异性识别HSD17B8蛋白，并揭示该蛋白在类固醇代谢相关组织中的差异表达。
2. **"Mitochondrial localization and functional analysis of HSD17B8 using specific antibodies"**
*Author: Tanaka K, et al.*
摘要：通过开发针对HSD17B8的单克隆抗体，研究者证实该蛋白主要定位于线粒体，并在体外实验中证明其参与17β-雌二醇的代谢调控，为HSD17B8在激素稳态中的作用提供了实验依据。
3. **"HSD17B8 expression profiling in prostate cancer: Insights from immunohistochemical analysis"**
*Author: Lee J, et al.*
摘要：利用商业化HSD17B8抗体对前列腺癌组织进行免疫组化分析，发现HSD17B8表达与肿瘤进展呈负相关，提示其可能作为抑制雄激素信号通路的潜在生物标志物。
(注：以上文献信息为示例性内容，实际文献需通过PubMed或Google Scholar等平台检索确认。)
The HSD17B8 antibody targets the 17β-hydroxysteroid dehydrogenase type 8 (HSD17B8) enzyme, a member of the 17β-HSD family involved in steroid metabolism. HSD17B8. encoded by the HSD17B8 gene, is a 26 kDa protein localized predominantly in mitochondria. It catalyzes the oxidation of estradiol to estrone and androstanediol to dihydrotestosterone, playing a regulatory role in sex hormone homeostasis. Unlike other 17β-HSD isoforms, HSD17B8 exhibits dual substrate specificity and functions as a short-chain dehydrogenase/reductase (SDR) with NAD⁺/NADH cofactor dependence. Its expression is detected in various tissues, including the liver, brain, and reproductive organs, suggesting roles beyond steroidogenesis, such as neuroprotection and lipid metabolism.
HSD17B8 antibodies are critical tools for studying the enzyme's expression, localization, and functional interactions in physiological and pathological contexts. They enable applications like Western blotting, immunohistochemistry, and ELISA to investigate HSD17B8's involvement in hormone-related cancers, metabolic disorders, or neurodegenerative diseases. Research using these antibodies has highlighted potential links between HSD17B8 dysregulation and conditions like Alzheimer’s disease, polycystic ovary syndrome (PCOS), and prostate cancer. Validated antibodies ensure specificity for distinguishing HSD17B8 from homologous enzymes, supporting mechanistic studies and therapeutic target exploration.
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