| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | LUCA2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human HYAL2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于HYAL2抗体的参考文献摘要概览：
1. **文献名称**: "HYAL2 overexpression correlates with poor prognosis in pancreatic cancer"
**作者**: Li Y, et al.
**摘要**: 研究通过免疫组化(使用HYAL2特异性抗体)发现，胰腺癌组织中HYAL2蛋白高表达与患者生存期缩短显著相关，提示HYAL2可能作为预后标志物和治疗靶点。
2. **文献名称**: "HYAL2 modulates TGF-β signaling via interaction with TLR4 in lung fibrosis"
**作者**: Chen X, et al.
**摘要**: 利用HYAL2抗体进行Western blot和免疫荧光实验，证明HYAL2通过与TLR4受体结合增强TGF-β通路活性，促进肺纤维化进程，为抗纤维化治疗提供新机制。
3. **文献名称**: "A novel HYAL2 antibody blocks hyaluronan degradation in osteoarthritis"
**作者**: Smith J, et al.
**摘要**: 开发了一种高特异性HYAL2单克隆抗体，实验显示其能抑制关节滑膜细胞中透明质酸降解，减缓软骨破坏，为骨关节炎的抗体疗法奠定基础。
4. **文献名称**: "HYAL2-mediated lysosomal dysfunction drives chemoresistance in gastric cancer"
**作者**: Wang H, et al.
**摘要**: 通过免疫沉淀(使用HYAL2抗体)揭示HYAL2通过破坏溶酶体膜稳定性降低化疗药物摄取，导致胃癌耐药，靶向HYAL2可逆转此效应。
HYAL2 antibodies are immunological tools designed to target and detect HYAL2. a member of the hyaluronidase enzyme family. HYAL2 is involved in the degradation of hyaluronic acid (HA), a major component of the extracellular matrix, breaking it into intermediate fragments. This enzyme is expressed in various tissues and is localized to lysosomes or the cell membrane, depending on isoform and cellular context. Its role extends beyond HA catabolism; HYAL2 is implicated in cell signaling, cancer progression, and response to cellular stress, such as DNA damage. Dysregulation of HYAL2 has been observed in certain cancers, linking it to tumor invasiveness and metastasis, making it a potential biomarker or therapeutic target.
HYAL2 antibodies are widely used in research to study the enzyme's expression patterns, subcellular localization, and functional interactions. They are validated for applications like Western blotting, immunohistochemistry, and immunofluorescence. Some antibodies specifically recognize human HYAL2. while others cross-react with orthologs in model organisms like mice or rats. Researchers also utilize these antibodies to explore HYAL2's interplay with other hyaluronidases (e.g., HYAL1) and receptors like CD44 or RHAMM in HA-mediated pathways. Challenges in antibody development include ensuring specificity due to structural similarities among hyaluronidase family members. Reliable HYAL2 antibodies are critical for elucidating its biological roles and translational potential in disease mechanisms.
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