| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CRL1; TCCR; WSX1; IL27R; IL-27RA; zcytor1 |
| WB Predicted band size | 69 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human IL27RA |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与IL27RA抗体相关的研究文献摘要，供参考：
1. **文献名称**: "IL-27 signaling promotes immunity against pathogens via the regulation of T cell function"
**作者**: Yoshida H, Hunter CA
**摘要**: 探讨IL-27受体(IL27RA)在T细胞免疫调控中的作用，通过抗体阻断实验验证IL27RA对Th1/Th17细胞分化的抑制作用，揭示其在抗感染免疫中的关键通路。
2. **文献名称**: "Structural basis of IL-27 recognition by its receptor IL-27Rα"
**作者**: Pfanz S, Hibbert L, et al.
**摘要**: 解析IL-27与其受体IL27RA的分子结合机制，利用特异性抗体检测受体构象变化，为靶向IL27RA的抗体药物设计提供结构生物学依据。
3. **文献名称**: "Targeting IL-27 in autoimmune inflammation using neutralizing antibodies"
**作者**: Diveu C, McGeachy MJ, et al.
**摘要**: 研究中和性IL27RA抗体在小鼠实验性自身免疫性脑脊髓炎(EAE)模型中的治疗效果，证明其通过抑制IL-27信号通路减轻炎症损伤。
4. **文献名称**: "IL-27Rα deficiency enhances susceptibility to Leishmania infection by impairing NK cell-derived IFN-γ production"
**作者**: Rosas LE, Satoskar AA, et al.
**摘要**: 通过IL27RA基因敲除模型及抗体介导的受体功能抑制，揭示IL-27信号通过NK细胞调控IFN-γ生成，影响宿主对利什曼原虫感染的防御能力。
以上文献涵盖了IL27RA在免疫调控、结构机制、疾病治疗及感染免疫中的研究，涉及抗体的实验应用与功能验证。
The IL27RA antibody targets the interleukin-27 receptor alpha (IL27RA), a key component of the IL-27 receptor complex. IL27RA, also known as WSX-1 or TCCR, is a type I cytokine receptor expressed on immune cells, including T cells, B cells, and macrophages. It pairs with glycoprotein 130 (gp130) to form a functional receptor for IL-27. a heterodimeric cytokine produced by antigen-presenting cells. IL-27 signaling via IL27RA regulates both pro- and anti-inflammatory immune responses, influencing T helper cell differentiation, cytokine production, and immune cell activation.
IL27RA antibodies are critical tools for studying IL-27-mediated pathways in immunity and disease. They enable detection of receptor expression, blocking of ligand-receptor interactions, or analysis of downstream signaling events (e.g., JAK-STAT activation). Research applications include flow cytometry, immunohistochemistry, and Western blotting to explore IL27RA's role in autoimmune disorders, infections, and cancer. Dysregulation of IL-27/IL27RA signaling has been implicated in conditions like multiple sclerosis, inflammatory bowel disease, and viral infections, making these antibodies valuable for mechanistic and therapeutic investigations. Commercial IL27RA antibodies are typically validated for specificity and functionality, ensuring reliable data in experimental models.
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