| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | BDA1; HHG2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human IHH |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于IHH抗体的3篇代表性文献的简要概括(注：内容为模拟示例，实际文献需通过学术数据库检索获取)：
1. **文献名称**：*Therapeutic Targeting of Indian Hedgehog (IHH) with Monoclonal Antibodies in Colorectal Cancer*
**作者**：Smith, J. et al.
**摘要**：本研究开发了一种靶向IHH蛋白的单克隆抗体，体外实验表明其可有效抑制Hedgehog信号通路，并在结直肠癌小鼠模型中显著减少肿瘤生长和转移，提示IHH抗体在癌症治疗中的潜力。
2. **文献名称**：*IHH Neutralizing Antibody Attenuates Pulmonary Fibrosis via Modulation of Epithelial-Mesenchymal Transition*
**作者**：Chen, L. et al.
**摘要**：通过大鼠肺纤维化模型，发现IHH抗体能够阻断IHH与PTCH1受体的结合，抑制上皮-间质转化(EMT)，减轻胶原沉积，为肺纤维化治疗提供了新策略。
3. **文献名称**：*Role of IHH Antibody in Cartilage Development: Insights from Chondrocyte-Specific Knockout Models*
**作者**：Yamamoto, K. et al.
**摘要**：研究利用IHH抗体干预小鼠胚胎软骨细胞，证实IHH信号缺失导致软骨分化异常和骨骼发育畸形，强调了IHH在骨形成中的关键作用及抗体工具的科研价值。
如需具体文献，建议通过PubMed或Google Scholar检索关键词“IHH antibody”“Indian Hedgehog therapeutic”等获取最新研究。
Indian Hedgehog (IHH) is a key member of the Hedgehog (Hh) signaling protein family, which plays critical roles in embryonic development, tissue patterning, and cellular differentiation. Discovered in the 1990s, the Hh pathway, including IHH, is evolutionarily conserved and regulates processes such as bone growth, cartilage formation, and gut homeostasis. IHH is particularly vital in endochondral ossification, where it coordinates chondrocyte proliferation and differentiation. Dysregulation of IHH signaling is linked to skeletal disorders (e.g., brachydactyly) and cancers (e.g., chondrosarcoma, gastrointestinal tumors).
Antibodies targeting IHH are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. They enable detection via techniques like immunohistochemistry, Western blotting, and ELISA, aiding research into developmental biology and disease mechanisms. In cancer research, IHH antibodies help elucidate its role in tumor proliferation, metastasis, and resistance to therapy. Additionally, they contribute to drug development, as aberrant Hh signaling is a therapeutic target. Small-molecule inhibitors (e.g., vismodegib) targeting the Hh pathway are already used clinically, but specificity and off-target effects remain challenges. IHH antibodies thus support biomarker discovery and validation for precision therapies. Their application spans basic research, diagnostic assays, and translational studies, underscoring their importance in understanding and modulating Hh-related pathologies.
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