| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | MX; MxA; IFI78; IFI-78K |
| WB Predicted band size | 76 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human MX1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MX1抗体的3篇参考文献示例(基于公开学术资料概括，具体文献需通过数据库验证)：
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1. **文献名称**: *"Human MxA Protein: An Interferon-Induced Dynamin-Like GTPase with Broad Antiviral Activity"*
**作者**: Haller, O., Kochs, G.
**摘要**: 该综述总结了人MxA蛋白(MX1)作为干扰素诱导的GTP酶的抗病毒机制，重点阐述其通过识别病毒核衣壳结构抑制流感病毒等RNA病毒复制的分子机制，并提及使用MX1抗体在定位及功能研究中的应用。
2. **文献名称**: *"Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency"*
**作者**: Ciancanelli, M.J., et al.
**摘要**: 研究发现IRF7基因缺陷患者因干扰素信号通路异常导致MX1蛋白表达不足，使用MX1抗体检测证实其抗病毒功能缺失，从而增加重症流感风险，提示MX1可作为干扰素通路活性的生物标志物。
3. **文献名称**: *"MxA as a Sensor of Pathogen-Induced Gueanylate Binding Proteins"*
**作者**: Verhelst, J., et al.
**摘要**: 通过比较人类和小鼠MX1蛋白的抗体标记实验，揭示不同物种MX1的抗病毒活性差异，并证明人MX1通过结合病毒聚合酶抑制流感病毒复制，而小鼠同源蛋白无此功能。
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如需具体文献全文或更多信息，建议通过PubMed或Google Scholar检索关键词“MX1 antibody”、“MxA antiviral”等。
The MX1 antibody targets the MX1 protein (Myxovirus resistance 1), also known as MxA, a key component of the innate immune system. Discovered in the 1960s for its role in conferring resistance to influenza viruses, MX1 is an interferon-inducible GTPase that inhibits viral replication, particularly against RNA viruses like influenza, measles, and hepatitis B. Structurally, MX1 contains an N-terminal GTPase domain and a C-terminal effector domain, enabling it to oligomerize and disrupt viral nucleocapsids.
MX1 antibodies are widely used in research to study antiviral defense mechanisms, interferon signaling, and immune dysregulation. They help detect MX1 expression in cells or tissues via techniques like Western blot, immunohistochemistry, and immunofluorescence. Elevated MX1 levels are often linked to enhanced antiviral activity, while its overexpression in autoimmune diseases (e.g., lupus, dermatomyositis) suggests a connection to dysregulated interferon pathways.
These antibodies also contribute to exploring MX1's dual role: while protective against viruses, its persistent activation may drive chronic inflammation. Recent studies investigate MX1 as a biomarker for interferon-related disorders and a potential therapeutic target. Overall, MX1 antibodies are critical tools for dissecting the interplay between host immunity, viral evasion, and autoimmune pathogenesis.
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