| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | IKIP |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human IKBIP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是基于学术文献模式的模拟参考文献示例(请注意，IKBIP相关研究较为有限，以下内容为假设性概括)：
1. **文献名称**：*IKBIP modulates NF-κB signaling in hepatocellular carcinoma through interaction with IKKβ*
**作者**：Li, X. et al.
**摘要**：本研究通过免疫共沉淀和Western blot技术，发现IKBIP蛋白通过与IKKβ结合调控NF-κB信号通路，促进肝癌细胞增殖。研究使用特异性IKBIP抗体验证其在肿瘤组织中的高表达。
2. **文献名称**：*Development of a novel monoclonal antibody against IKBIP for glioblastoma diagnostics*
**作者**：Chen, Y. et al.
**摘要**：团队开发了一种高特异性抗IKBIP单克隆抗体，并用于胶质母细胞瘤的免疫组化检测，证实IKBIP表达与患者预后不良相关，提示其作为潜在生物标志物的价值。
3. **文献名称**：*IKBIP deficiency exacerbates inflammation via dysregulated TLR4 signaling*
**作者**：Wang, H. et al.
**摘要**：通过构建IKBIP基因敲除小鼠模型，结合抗体介导的蛋白定位分析，揭示了IKBIP在TLR4介导的炎症反应中的负调控作用，为自身免疫疾病机制提供新见解。
**备注**：实际研究中关于IKBIP抗体的文献较少，建议通过PubMed或Google Scholar以“IKBIP antibody”或“IKK interacting protein”为关键词检索最新成果，并注意验证抗体特异性及研究背景。
The IKBIP (Inhibitor of κB Interacting Protein) antibody is a tool used to study the IKBIP protein, which plays a regulatory role in the NF-κB signaling pathway. IKBIP interacts with inhibitor of κB (IκB) proteins, key regulators that sequester NF-κB transcription factors in the cytoplasm. Upon cellular stimulation (e.g., cytokines, pathogens), IκB undergoes phosphorylation and degradation, releasing NF-κB to activate pro-inflammatory and survival genes. IKBIP modulates this process by influencing IκB stability or interactions with the IKK (IκB kinase) complex, though its precise mechanisms remain under investigation.
IKBIP is implicated in diverse physiological and pathological contexts, including inflammation, cancer, and immune responses. Dysregulation of NF-κB signaling is linked to chronic inflammatory diseases, autoimmune disorders, and tumorigenesis, making IKBIP a potential biomarker or therapeutic target. The IKBIP antibody is utilized in techniques like Western blotting, immunoprecipitation, and immunofluorescence to detect protein expression, localization, and interaction partners. Recent studies highlight its role in cancer progression, where altered IKBIP levels correlate with tumor invasiveness or drug resistance. Further research aims to clarify its tissue-specific functions and therapeutic relevance in diseases driven by NF-κB dysregulation.
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