Rabbit Polyclonal MBNL3 Antibody

The MBNL3 antibody is a research tool designed to detect Muscleblind-like protein 3 (MBNL3), a member of the MBNL family of RNA-binding proteins. MBNL proteins, including MBNL1. MBNL2. and MBNL3. regulate RNA processing steps such as splicing, localization, and stability. They play critical roles in muscle and neuronal development, with dysregulation linked to myotonic dystrophy (DM), a genetic disorder caused by expanded nucleotide repeats. MBNL3 shares conserved zinc finger domains that mediate RNA binding but exhibits distinct expression patterns and functions compared to other family members. While MBNL1 and MBNL2 are widely expressed, MBNL3 is predominantly found in placental and embryonic tissues, suggesting roles in cellular differentiation and reprogramming. Studies highlight its involvement in maintaining pluripotency in stem cells and influencing cancer progression through pathways like epithelial-mesenchymal transition (EMT). The MBNL3 antibody enables researchers to investigate its expression, subcellular localization (nuclear/cytoplasmic), and interactions in developmental or disease contexts. It is commonly used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to explore MBNL3’s contribution to RNA-mediated mechanisms in disorders such as DM, cancer, and developmental anomalies. Commercial antibodies are typically validated for specificity against human, mouse, or rat MBNL3 isoforms.