Rabbit Polyclonal MRPL28 Antibody

The MRPL28 antibody is a research tool designed to detect mitochondrial ribosomal protein L28 (MRPL28), a component of the large subunit of the mitochondrial ribosome. Mitochondrial ribosomes are essential for translating mitochondrial DNA-encoded mRNAs into proteins, which are critical for oxidative phosphorylation (OXPHOS) and cellular energy production. MRPL28. encoded by the nuclear genome, is imported into mitochondria and plays a structural or functional role in assembling or stabilizing the ribosome. Antibodies targeting MRPL28 are commonly used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study its expression, localization, and interactions in various tissues or cell types. These studies help elucidate mitochondrial translation mechanisms, metabolic disorders, or diseases linked to mitochondrial dysfunction, such as neurodegenerative conditions, cancer, or inherited mitochondrial disorders. Validated MRPL28 antibodies (polyclonal or monoclonal, often raised in rabbits or mice) are characterized for specificity using knockout controls or siRNA-mediated knockdown. Research involving MRPL28 may also explore its role in stress responses, apoptosis, or as a biomarker for mitochondrial health. Proper antibody selection requires attention to species reactivity, application compatibility, and peer-reviewed validation data to ensure reliable experimental outcomes.