Rabbit Polyclonal NDUFV2 Antibody

The NDUFV2 antibody is a crucial tool in studying the NADH:ubiquinone oxidoreductase core subunit V2 (NDUFV2), a key component of mitochondrial Complex I (NADH dehydrogenase) in the electron transport chain. Encoded by the nuclear gene NDUFV2 located on chromosome 18q12.2. this 24 kDa protein is anchored to the mitochondrial inner membrane and participates in electron transfer during oxidative phosphorylation. Dysregulation of NDUFV2 has been linked to mitochondrial disorders, neurodegenerative diseases (e.g., Parkinson's and Alzheimer's), and certain cancers. Researchers employ NDUFV2 antibodies primarily for detecting protein expression levels via Western blotting, immunohistochemistry, or immunofluorescence, often to investigate mitochondrial dysfunction in disease models or therapeutic responses. These antibodies also facilitate studies of Complex I assembly and activity, as NDUFV2 mutations are associated with Leigh syndrome and other pediatric encephalopathies. Validation typically includes knockout cell line controls to ensure specificity. Recent applications extend to exploring metabolic reprogramming in cancer and aging, highlighting its role in cellular energy homeostasis. Commercial NDUFV2 antibodies are usually raised against conserved epitopes, with species reactivity spanning human, mouse, and rat samples. Proper storage at -20°C and avoidance of repeated freeze-thaw cycles are recommended for maintaining antibody stability.