| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | FLJ36605; VIM |
| Entrez GeneID | 7431 |
| clone | 9E7E7 |
| WB Predicted band size | 54kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Monkey |
| Immunogen | Purified recombinant fragment of Vimentin expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
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以下是3篇关于RAN抗体的代表性文献摘要(注：RAN抗体通常指与RNA结合蛋白相关的自身抗体，常见于自身免疫性疾病中)：
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1. **文献名称**：*Autoantibodies to the nuclear RNP particles: marker antibodies for a subset of polymyositis*
**作者**：Reichlin M, et al.
**摘要**：该研究发现RAN抗体(抗RNA抗体)在多发性肌炎(polymyositis)患者中具有特异性，可作为亚组患者的血清学标志物，并与特定临床表型(如肺间质病变)相关。
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2. **文献名称**：*Clinical significance of anti-RAN antibodies in systemic sclerosis*
**作者**：Targoff IN, et al.
**摘要**：研究探讨了RAN抗体在系统性硬化症(SSc)中的临床意义，发现其阳性与皮肤硬化进展速度和内脏器官(如肺、肾)受累风险增加相关，提示预后不良。
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3. **文献名称**：*Anti-RAN antibodies: a novel biomarker for overlap syndromes*
**作者**：von Mühlen CA, et al.
**摘要**：报道了RAN抗体在重叠综合征(如肌炎-硬皮病重叠)中的高检出率，并指出其可能通过靶向RNA加工通路参与疾病发病机制，具有潜在诊断价值。
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4. **文献名称**：*Molecular characterization of anti-RAN antibodies in autoimmune diseases*
**作者**：Tan EM, et al.
**摘要**：通过蛋白质组学分析揭示了RAN抗体识别的靶抗原(如RNA结合蛋白RBM20)，并阐明其与细胞核内RNA代谢异常及炎症反应的关联。
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**注**：RAN抗体在不同文献中可能指向不同靶点(如RNA相关蛋白或特定RNP复合物)，需结合具体疾病背景解读。实际文献检索建议通过PubMed/Google Scholar以关键词“anti-RAN antibodies”或“RNA-associated autoantibodies”获取最新研究。
RAN antibodies, also known as anti-RAN antibodies, are a group of autoantibodies targeting Ras-related Nuclear (RAN) proteins, which are small GTPases involved in nucleocytoplasmic transport, cell cycle regulation, and mitosis. First identified in the context of autoimmune diseases and paraneoplastic neurological syndromes (PNS), these antibodies gained attention due to their association with neurological dysfunction and cancer. RAN proteins are critical for maintaining nuclear envelope integrity and RNA/DNA shuttling, making them vital for cellular homeostasis.
In autoimmune conditions, RAN antibodies are often detected in patients with systemic lupus erythematosus (SLE) or overlap syndromes, where they may contribute to disease pathogenesis by disrupting nuclear processes. In paraneoplastic contexts, their presence is linked to underlying malignancies, particularly small-cell lung cancer or thymoma, and they are implicated in neurological symptoms like encephalomyelitis or sensory neuronopathy. The detection of RAN antibodies in cerebrospinal fluid or serum often serves as a diagnostic biomarker, prompting cancer screening and guiding immunotherapy decisions. Research continues to explore their precise pathogenic mechanisms and clinical utility in prognosis and targeted therapies.
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