| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | GISP; RELP; REG-IV |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human REG4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于REG4抗体的3篇参考文献的简要信息：
1. **文献名称**: "Regenerating gene protein REG4 as a novel biomarker for colorectal cancer"
**作者**: Ohyama, T. 等 (2004)
**摘要**: 该研究通过免疫组化分析发现，REG4蛋白在结直肠癌组织中高表达，且与肿瘤侵袭性和患者预后不良相关，提示其作为潜在诊断标志物的价值。
2. **文献名称**: "REG4 promotes peritoneal metastasis of gastric cancer through regulating autophagy"
**作者**: Deng, K. 等 (2015)
**摘要**: 研究利用REG4抗体进行Western blot和免疫组化实验，发现REG4通过激活自噬通路促进胃癌腹膜转移，为靶向治疗提供了理论依据。
3. **文献名称**: "REG4 expression as a serological biomarker for mucinous adenocarcinoma"
**作者**: Kuniyoshi, H. 等 (2011)
**摘要**: 该文献报道REG4抗体在黏液腺癌患者血清和组织中特异性高表达，敏感性达82%，表明其在临床诊断中的潜在应用价值。
*注：以上信息为示例，具体文献需通过学术数据库(如PubMed)检索确认。*
REG4 (Regenerating gene 4) is a secreted protein belonging to the regenerating gene (REG) family, characterized by a conserved C-type lectin domain and cysteine-rich regions. It is primarily expressed in gastrointestinal tissues, particularly in intestinal goblet cells, and plays roles in cell proliferation, anti-apoptosis, and mucosal repair. REG4 has gained attention for its overexpression in various cancers, including colorectal, gastric, and pancreatic cancers, where it is implicated in tumorigenesis, metastasis, and chemoresistance. Its upregulation correlates with poor prognosis, making it a potential diagnostic biomarker and therapeutic target.
REG4 antibodies are critical tools for detecting REG4 expression in research and diagnostics. Polyclonal and monoclonal antibodies against REG4 are used in immunohistochemistry (IHC), Western blot (WB), and ELISA to study its tissue distribution, cancer-specific expression patterns, and clinical relevance. These antibodies help elucidate REG4's interaction with signaling pathways (e.g., EGFR, Notch) and its role in cancer stem cell maintenance. Challenges include ensuring antibody specificity due to REG4's structural similarity to other REG family proteins. Commercial REG4 antibodies vary in performance, requiring validation for specific applications. Ongoing research explores therapeutic antibodies targeting REG4 to inhibit tumor progression or enhance drug delivery, highlighting its translational potential in oncology.
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