Rabbit Polyclonal RGS5 Antibody

The Regulator of G protein Signaling 5 (RGS5) is a member of the RGS protein family, which plays a critical role in modulating G protein-coupled receptor (GPCR) signaling pathways. RGS5 acts as a GTPase-activating protein (GAP) for Gα subunits, accelerating the hydrolysis of GTP to terminate signaling. It is prominently expressed in vascular smooth muscle cells, pericytes, and certain tumor-associated stromal cells, where it regulates vascular tone, angiogenesis, and tissue remodeling. Research highlights its involvement in pathological conditions, including hypertension, fibrosis, and cancer. In tumors, RGS5 is linked to abnormal vascular maturation and has been proposed as a biomarker for tumor vessel normalization therapy. Antibodies targeting RGS5 are essential tools for detecting its expression and localization in tissues or cell cultures via techniques like Western blotting, immunohistochemistry, or immunofluorescence. These antibodies aid in studying RGS5's role in cellular processes, disease mechanisms, and potential therapeutic targeting. Specificity and validation (e.g., knockout controls) are crucial due to homology among RGS family members. Studies using RGS5 antibodies have provided insights into its dual roles in promoting or suppressing diseases, depending on context, making it a molecule of interest in cardiovascular and cancer research.