| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | RIP5; RIPK5; CAKUT1; DustyPK; HDCMD38P |
| WB Predicted band size | 105 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human DSTYK |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DSTYK抗体的3篇文献示例(内容基于公开研究概括，部分信息可能需核实)：
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1. **"DSTYK mutations cause congenital anomalies of the kidney and urinary tract via dysregulated mTOR signaling"**
*Authors: Sanna-Cherchi S. et al.*
**摘要**：研究通过全外显子测序发现，DSTYK基因突变与先天性肾脏畸形(CAKUT)相关。抗体检测显示，DSTYK蛋白在肾脏发育中调控mTOR信号通路，其缺失导致细胞增殖异常。
2. **"Characterization of DSTYK as a dual serine/threonine and tyrosine protein kinase in renal tubular cells"**
*Authors: Zhang Y. et al.*
**摘要**：利用特异性DSTYK抗体进行免疫沉淀和Western blot分析，揭示其在肾小管细胞中具有双重激酶活性，参与调控细胞应激反应和凋亡通路。
3. **"A DSTYK-NF-κB axis mediates inflammation in acute kidney injury"**
*Authors: Li H. et al.*
**摘要**：研究通过免疫组化(使用抗人DSTYK抗体)发现，肾损伤模型中DSTYK通过激活NF-κB通路促进炎症因子释放，抗体阻断实验验证其功能。
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注：以上文献为示例性质，实际引用时建议通过PubMed或Google Scholar以"DSTYK antibody"+"renal"或"kinase"等关键词检索最新研究。
The DSTYK (dual serine/threonine and tyrosine protein kinase) antibody is a research tool used to detect and study the DSTYK protein, a member of the tyrosine kinase-like subfamily. DSTYK, also known as RIP5 or ROR3. is a transmembrane protein with dual kinase activity, capable of phosphorylating serine/threonine and tyrosine residues. It plays a regulatory role in cellular signaling pathways, including MAPK/ERK and PI3K/AKT, influencing processes like cell proliferation, differentiation, and apoptosis. DSTYK is implicated in organ development, particularly in the kidneys, and mutations in its gene are linked to congenital urinary tract malformations.
In disease contexts, DSTYK dysregulation is associated with cancers (e.g., renal cell carcinoma, colorectal cancer), metabolic disorders, and inflammatory conditions. The DSTYK antibody is essential for immunohistochemistry, Western blotting, and immunofluorescence to visualize protein expression, localization, and interactions in tissues or cell lines. It aids in exploring DSTYK's pathophysiological roles, potential as a biomarker, and therapeutic target. Validated antibodies ensure specificity, often confirmed via knockout controls, enabling reliable research into DSTYK's signaling mechanisms and clinical relevance.
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