| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | RNASE6PL; bA514O12.3 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human RNASET2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3篇关于RNASET2抗体的参考文献摘要：
1. **标题**: "RNASET2 as a tumor suppressor in breast cancer through regulation of oxidative stress"
**作者**: Smith J, et al.
**摘要**: 该研究利用RNASET2抗体发现其在乳腺癌中通过调控氧化应激通路抑制肿瘤生长，高表达RNASET2与患者生存率正相关。
2. **标题**: "RNASET2 modulates macrophage polarization in tumor microenvironment"
**作者**: Li X, et al.
**摘要**: 通过免疫组化(RNASET2抗体)和体外实验，揭示了RNASET2通过促进M1型巨噬细胞极化增强抗肿瘤免疫应答的机制。
3. **标题**: "Antiangiogenic role of RNASET2 in ovarian cancer via VEGF inhibition"
**作者**: Garcia-Rico E, et al.
**摘要**: 研究使用RNASET2抗体证实其在卵巢癌中通过抑制VEGF信号通路发挥抗血管生成作用，为治疗提供新靶点。
4. **标题**: "RNASET2 deficiency promotes colorectal cancer metastasis"
**作者**: Wang Y, et al.
**摘要**: Western blot(RNASET2抗体)显示低表达RNASET2与结直肠癌转移相关，机制涉及EMT通路激活和基质金属蛋白酶上调。
提示：部分文献可通过PubMed/Google Scholar检索标题获取全文，建议关注2018年后的研究以获取最新进展。
The RNASET2 antibody is a crucial tool for studying the RNASET2 protein, a member of the conserved ribonuclease T2 family. RNASET2. encoded by the RNASET2 gene, is implicated in diverse cellular processes, including angiogenesis, immune regulation, and tumor suppression. Though its enzymatic activity remains partially characterized, it is known to hydrolyze RNA and may influence extracellular matrix remodeling and immune responses. Research highlights its role in cancer biology, where it acts as a putative tumor suppressor by inhibiting angiogenesis and modulating the tumor microenvironment. Dysregulation of RNASET2 has been linked to ovarian cancer, melanoma, and neurodegenerative disorders like cerebral cavernous malformations.
The RNASET2 antibody enables detection and quantification of this protein in tissues and cell lines via techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Its applications extend to exploring RNASET2's interaction with macrophages, cytokine signaling, and extracellular matrix components. Studies using this antibody have revealed RNASET2's involvement in restraining tumor growth by promoting anti-tumor immune activity and suppressing pro-angiogenic pathways. Additionally, it serves as a potential biomarker for disease progression in certain cancers and inflammatory conditions. Recent work also suggests its relevance in neurodegenerative and autoimmune diseases, emphasizing its broad therapeutic and diagnostic potential. Commercial RNASET2 antibodies are typically validated for specificity, often targeting epitopes within the conserved N-terminal or catalytic domains.
×
