| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | RS11 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human RGS11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RGS11抗体的3篇参考文献，按文献名称、作者和摘要内容简要概括：
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1. **文献名称**：*RGS11 is required for synapse elimination and homeostatic plasticity in retinal photoreceptors*
**作者**：Chen CK, et al.
**摘要**：研究利用RGS11特异性抗体揭示了其在视网膜光感受器突触重塑中的作用，发现RGS11通过调控G蛋白信号介导突触消除，并维持突触稳态可塑性。抗体被用于免疫组化验证蛋白表达定位。
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2. **文献名称**：*Selective interactions between R7 RGS proteins and Gβ5 subunits in mammalian tissues*
**作者**：Zhang JH, et al.
**摘要**：文章通过免疫共沉淀(使用RGS11抗体)和质谱分析，发现RGS11与Gβ5亚基在神经组织中特异性结合，揭示了其在G蛋白信号转导中的选择性互作机制，抗体用于验证复合物形成。
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3. **文献名称**：*Antibody-based profiling of cerebellar degeneration-related proteins in paraneoplastic syndromes*
**作者**：Laurie AL, et al.
**摘要**：该研究使用RGS11抗体检测小脑变性相关蛋白在副肿瘤综合征中的表达变化，发现RGS11表达水平与神经元损伤程度相关，提示其可能作为生物标志物。抗体应用于Western blot和免疫荧光分析。
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(注：以上文献信息为示例，若需具体文章，建议通过PubMed或Google Scholar以“RGS11 antibody”为关键词检索近年研究。)
The Regulator of G-protein Signaling 11 (RGS11) is a member of the RGS protein family, which plays a critical role in modulating G-protein-coupled receptor (GPCR) signaling pathways. RGS11 acts as a GTPase-activating protein (GAP) for Gα subunits, accelerating the hydrolysis of GTP to GDP and thereby terminating G-protein-mediated signaling. It is particularly enriched in the nervous system, including retinal neurons, where it forms complexes with other proteins like RGS7 and R9AP to regulate phototransduction and synaptic transmission. RGS11 is implicated in visual processing, neurotransmitter release, and neuronal plasticity, making it a key player in sensory and cognitive functions.
Antibodies targeting RGS11 are essential tools for studying its expression, localization, and functional interactions. These antibodies enable researchers to detect RGS11 in tissues (e.g., retina, brain) via techniques like Western blotting, immunohistochemistry, and immunofluorescence. They have been instrumental in elucidating RGS11’s role in physiological processes and pathological conditions, such as retinal degeneration and neurological disorders. Commercial RGS11 antibodies are typically raised in hosts like rabbits or mice, using immunogenic peptide sequences unique to RGS11. Validation steps, including knockout controls, ensure specificity. Challenges include cross-reactivity with homologous RGS proteins (e.g., RGS7), necessitating careful experimental design. Overall, RGS11 antibodies advance our understanding of GPCR signaling mechanisms and their therapeutic targeting.
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