| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | COX2; COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; GRIPGHS |
| WB Predicted band size | 69 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human PTGS2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PTGS2(COX-2)抗体的3篇示例参考文献(内容为模拟，仅供参考)：
1. **文献名称**：*"Immunohistochemical Analysis of PTGS2 Expression in Colorectal Cancer and Its Prognostic Significance"*
**作者**：Smith A, et al.
**摘要**：该研究通过免疫组化分析PTGS2抗体在结直肠癌组织中的表达水平，发现PTGS2高表达与肿瘤进展和患者生存率降低显著相关，提示其可作为预后标志物。
2. **文献名称**：*"Comparative Study of PTGS2 Antibody Specificity in Inflammatory Models"*
**作者**：Chen L, et al.
**摘要**：研究比较了多种市售PTGS2抗体的特异性，发现部分抗体在Western blot和免疫荧光中存在交叉反应，强调抗体验证对炎症相关研究的重要性。
3. **文献名称**：*"PTGS2 Inhibition and Antibody Localization in Breast Cancer Microenvironment"*
**作者**：García-Rojas M, et al.
**摘要**：利用PTGS2抗体定位乳腺癌微环境中的表达区域，发现其与肿瘤相关巨噬细胞浸润相关，为靶向治疗提供潜在方向。
(注：以上文献为示例，实际引用请通过PubMed、Web of Science等平台检索真实研究。)
The PTGS2 antibody is a crucial tool in biomedical research for detecting and analyzing the expression of Prostaglandin-Endoperoxide Synthase 2 (PTGS2), also known as cyclooxygenase-2 (COX-2). PTGS2 is an inducible enzyme involved in prostaglandin biosynthesis, playing a key role in inflammation, pain response, and fever. Unlike its constitutively expressed isoform PTGS1 (COX-1), PTGS2 is upregulated during inflammatory or pathological conditions, such as infection, cancer, or tissue injury, making it a biomarker for disease progression and therapeutic targeting.
PTGS2 antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study PTGS2 protein levels in tissues or cells. They help elucidate PTGS2's role in conditions like arthritis, cardiovascular diseases, and malignancies, where its overexpression is linked to tumor growth, angiogenesis, and metastasis. These antibodies are also vital in evaluating the efficacy of COX-2 inhibitors (e.g., celecoxib) in drug development.
Specificity is a critical factor, as PTGS2 shares structural homology with PTGS1. High-quality PTGS2 antibodies are validated to minimize cross-reactivity, ensuring accurate detection. Available as monoclonal or polyclonal forms, they cater to diverse experimental needs. Research using PTGS2 antibodies continues to advance understanding of inflammatory pathways and therapeutic strategies, bridging molecular mechanisms with clinical applications.
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