| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | VLCS; FATP2; VLACS; ACSVL1; FACVL1; hFACVL1; HsT17226 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human SLC27A2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SLC27A2抗体的3篇参考文献，按文献名称、作者和摘要内容概括整理：
1. **文献名称**：*"Role of FATP2 in human hepatocellular carcinoma lipid metabolism and progression"*
**作者**：Li Y, et al.
**摘要**：该研究利用SLC27A2(FATP2)特异性抗体，通过免疫组化和Western blot分析肝癌组织中FATP2的蛋白表达水平，发现其高表达与脂质代谢异常和肿瘤恶性进展相关。
2. **文献名称**：*"SLC27A2 regulates intestinal fatty acid absorption and modulates metabolic syndrome in mice"*
**作者**：Smith J, et al.
**摘要**：通过构建SLC27A2基因敲除小鼠模型，结合抗体验证蛋白表达缺失，揭示了SLC27A2在小肠脂肪酸吸收中的关键作用，并发现其缺失可改善高脂饮食诱导的代谢综合征。
3. **文献名称**：*"Antibody-based profiling of SLC27A2 in renal cell carcinoma identifies a therapeutic target for lipid storage disorders"*
**作者**：Chen R, et al.
**摘要**：研究开发了一种高特异性SLC27A2单克隆抗体，用于检测肾癌细胞中SLC27A2的亚细胞定位，发现其过表达促进脂质蓄积，提示其作为治疗靶点的潜力。
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**注**：以上文献信息为示例性概括，实际文献需通过PubMed/Google Scholar等平台检索确认。若需具体文献，建议使用关键词“SLC27A2 antibody”或“FATP2 antibody”结合研究领域(如癌症、代谢疾病)进一步筛选。
SLC27A2 (solute carrier family 27 member 2), also known as fatty acid transport protein 2 (FATP2), is a membrane-bound protein involved in cellular uptake and metabolism of long-chain fatty acids. It belongs to the SLC27 family of fatty acid transporters and is highly expressed in tissues with active lipid metabolism, including the liver, small intestine, and adipose tissue. SLC27A2 facilitates fatty acid translocation across membranes and activates them via esterification with Coenzyme A, playing a critical role in lipid homeostasis, energy production, and inflammatory signaling.
Antibodies targeting SLC27A2 are essential tools for studying its expression, localization, and function in physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate SLC27A2's role in metabolic disorders (e.g., obesity, diabetes), non-alcoholic fatty liver disease (NAFLD), and cancer, where altered fatty acid metabolism is implicated. Specific SLC27A2 antibodies can help identify its subcellular distribution (primarily in the endoplasmic reticulum and plasma membrane) and interactions with other metabolic regulators. Validating antibody specificity via knockout controls or siRNA silencing is crucial due to potential cross-reactivity with other FATPs. Research on SLC27A2 antibodies contributes to understanding lipid dysregulation mechanisms and developing therapeutic strategies targeting fatty acid metabolism pathways.
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