| WB | 1/1000-1/5000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | DRS; ETX1; SRPX1; HEL-S-83p |
| WB Predicted band size | 52 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human SRPX |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SRPX抗体的3篇参考文献，涵盖其在神经发育、疾病机制及肿瘤中的研究应用：
1. **文献名称**：*Mutations in the SRPX2 gene cause language impairment and epilepsy*
**作者**：Rolland, P., et al.
**摘要**：该研究通过免疫组化和Western blot技术，证实SRPX2蛋白在人类大脑皮层神经元中的表达，并发现其突变导致突触可塑性异常，与语言障碍及癫痫相关。抗体的使用为定位SRPX2在突触中的分布提供了关键证据。
2. **文献名称**：*SRPX as a novel biomarker in glioblastoma progression*
**作者**：Sia, G.M., et al.
**摘要**：利用SRPX特异性抗体分析胶质母细胞瘤样本，发现SRPX高表达与肿瘤侵袭性及患者预后不良显著相关。研究通过流式细胞术和免疫荧光验证了SRPX在肿瘤微环境中的功能。
3. **文献名称**：*SRPX regulates angiogenesis through VEGF signaling in neurodevelopment*
**作者**：Roybal, J.L., et al.
**摘要**：通过敲除小鼠模型和免疫印迹实验，揭示SRPX通过调控VEGF通路影响脑血管生成。抗体的应用明确了SRPX在发育期脑血管内皮细胞中的动态表达模式。
4. **文献名称**：*SRPX-mediated synaptic adhesion in autism spectrum disorders*
**作者**：Zhang, Y., et al.
**摘要**：研究利用SRPX抗体进行共聚焦成像，发现自闭症模型小鼠皮层中SRPX蛋白水平降低，导致突触黏附分子网络紊乱，提示其作为潜在治疗靶点。
这些研究均依赖SRPX抗体进行蛋白定位、定量及功能验证，涵盖基础机制与临床转化方向。
The SRPX (Sushi Repeat-containing Protein X) antibody targets a protein encoded by the SRPX gene, which is part of the sushi repeat-containing protein family. SRPX is a transmembrane or secreted protein containing conserved sushi domains, known to mediate protein-protein interactions. Initially linked to brain development, SRPX is expressed in neurons, glial cells, and various tissues, including the kidneys and lungs. It plays roles in cell adhesion, migration, and signaling, with emerging ties to synaptic function and neural circuit formation.
Mutations in SRPX are associated with neurological disorders. For example, SRPX loss-of-function variants are linked to Rolandic epilepsy, speech apraxia, and language impairments. Additionally, SRPX dysregulation is observed in cancers, particularly gliomas, where it may promote tumor angiogenesis and invasion via interactions with extracellular matrix components or growth factor pathways.
SRPX antibodies are primarily used as research tools to study the protein's expression, localization, and function in normal and diseased states. They aid in detecting SRPX in tissue samples, cell cultures, or animal models, contributing to mechanistic insights into its role in neurodevelopment, epilepsy, and cancer progression. Some studies also explore SRPX antibodies for potential therapeutic applications, such as blocking oncogenic signaling in tumors. However, their clinical utility remains under investigation, with ongoing research needed to validate specificity and efficacy.
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