Rabbit Polyclonal SLC25A26 Antibody

The SLC25A26 antibody is a research tool designed to detect and study the SLC25A26 protein, a member of the solute carrier family 25 (SLC25) of mitochondrial carrier proteins. SLC25A26. also known as SAM carrier or S-Adenosylmethionine mitochondrial carrier, facilitates the transport of S-adenosylmethionine (SAM) across the mitochondrial inner membrane. SAM is a critical methyl donor for mitochondrial methylation processes, including the modification of mitochondrial DNA, RNA, and proteins. Dysregulation of SLC25A26 has been implicated in metabolic disorders, mitochondrial dysfunction, and diseases such as cancer or neurodegenerative conditions. The antibody is commonly used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess protein expression, localization, and abundance in tissues or cultured cells. Validation of SLC25A26 antibodies typically involves specificity tests, such as siRNA knockdown or knockout controls, to confirm minimal cross-reactivity with other mitochondrial carriers. Researchers utilize these antibodies to explore SLC25A26's role in mitochondrial one-carbon metabolism, epigenetics, and cellular energy homeostasis. Its study contributes to understanding how SAM transport impacts mitochondrial function and disease mechanisms, making it a key target in metabolic and biomedical research.