Rabbit Polyclonal SLITRK6 Antibody

The SLITRK6 antibody targets SLITRK6. a member of the SLITRK family of transmembrane proteins implicated in neuronal development and synaptic regulation. SLITRK6 (Slit and Trk-like family member 6) is primarily expressed in sensory systems, including the inner ear and retina, and plays roles in neural circuit formation, cell adhesion, and survival. Structurally, it contains leucine-rich repeats (LRRs) and a conserved neurotrophin receptor homology domain, facilitating interactions with extracellular ligands and intracellular signaling pathways. Dysregulation of SLITRK6 has been linked to sensory disorders; mutations are associated with congenital hearing loss and retinal degeneration in Usher syndrome. The SLITRK6 antibody is a critical tool for studying its expression, localization, and function in neuronal and sensory tissues. Researchers utilize it in techniques like immunohistochemistry, Western blotting, and immunofluorescence to explore SLITRK6's role in developmental biology and disease mechanisms. Recent studies highlight its potential as a biomarker for sensory pathologies and a therapeutic target. However, its broader physiological roles outside sensory systems remain under investigation. Validated antibodies are essential for distinguishing SLITRK6 from homologous family members (SLITRK1-5) and clarifying its unique contributions to neural health and disease.