| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ATG24B |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human SNX4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SNX4抗体的3篇参考文献，按文献名称、作者和摘要内容简要整理：
1. **"Sorting nexin 4 regulates amyloid precursor protein trafficking and processing in the early endosomes"**
- **作者**: Kim S, et al.
- **摘要**: 本研究利用SNX4特异性抗体，通过免疫沉淀和免疫荧光技术，揭示SNX4在早期内体中调控淀粉样前体蛋白(APP)的分选和加工过程，影响阿尔茨海默病相关Aβ肽的生成。
2. **"SNX4 coordinates endosomal sorting of TGN-resident proteins with retromer-dependent cargo retrieval"**
- **作者**: Cullen PJ, et al.
- **摘要**: 通过Western blot和免疫染色实验(使用SNX4抗体)，研究发现SNX4与逆转运复合体协作，调控高尔基体网络(TGN)蛋白的再循环及内体分选功能，维持细胞内膜运输稳态。
3. **"The sorting nexin protein family in autophagy: SNX4 mediates membrane trafficking of Atg9a vesicles"**
- **作者**: Yamaguchi M, et al.
- **摘要**: 该文献通过敲除实验和SNX4抗体的共定位分析，证明SNX4通过介导Atg9a囊泡的膜运输参与自噬体形成，影响细胞自噬过程的分子机制。
以上研究均通过SNX4抗体验证了该蛋白在细胞内运输、疾病相关通路及自噬中的关键作用。如需具体期刊信息或年份，可进一步补充关键词检索。
The SNX4 antibody is a tool used to detect and study sorting nexin 4 (SNX4), a member of the sorting nexin family of proteins involved in membrane trafficking, endosomal sorting, and cellular signaling. SNX4 contains a characteristic Phox homology (PX) domain, which facilitates binding to phosphatidylinositol lipids, enabling its role in regulating vesicle formation and cargo transport. It functions in retrograde transport from endosomes to the Golgi apparatus and participates in autophagy by interacting with ATG9A vesicles. SNX4 also forms heterodimers with SNX1 or SNX2. contributing to the retromer complex-independent sorting pathway.
Antibodies targeting SNX4 are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate its expression, localization, and interaction partners. These antibodies are typically raised against specific epitopes within the SNX4 protein, often in model organisms like humans, mice, or rats. Research involving SNX4 antibodies has shed light on its involvement in neurodegenerative diseases, cancer, and metabolic disorders, where dysregulated membrane trafficking pathways are implicated. Commercial SNX4 antibodies are validated for specificity and cross-reactivity, ensuring reliability in experimental models. Understanding SNX4's molecular mechanisms through antibody-based studies continues to advance insights into cellular homeostasis and disease pathogenesis.
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