| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | RRP14 |
| WB Predicted band size | 41 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human SURF6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于 **SURF6 抗体** 的模拟参考文献示例(实际引用请核实原文)：
---
1. **标题**：*"Surfeit locus gene SURF6 regulates ribosome biogenesis and cell proliferation"*
**作者**：Huang, X., Smith, C., & Williams, B. R.
**摘要**：研究通过生成 SURF6 特异性抗体，发现 SURF6 在核糖体 RNA 加工中起关键作用，敲低 SURF6 导致细胞增殖抑制和核仁结构异常。
2. **标题**：*"Characterization of SURF6 antibody for detecting nucleolar protein dynamics"*
**作者**：Yoshihama, M., & Kenmochi, N.
**摘要**：开发了一种高特异性 SURF6 多克隆抗体，通过免疫荧光和 Western blot 验证其在哺乳动物细胞中的定位，证明 SURF6 与核糖体生物合成因子相互作用。
3. **标题**：*"SURF6 expression correlates with cancer cell growth and drug resistance"*
**作者**：Zhang, L., et al.
**摘要**：利用 SURF6 抗体分析癌症组织样本，发现 SURF6 高表达与肿瘤进展和化疗耐药相关，提示其作为潜在治疗靶点。
4. **标题**：*"Functional analysis of SURF6 in zebrafish development using antibody-based knockdown"*
**作者**：Garcia, A., & Nguyen, P. D.
**摘要**：通过 SURF6 抗体介导的功能阻断实验，揭示 SURF6 在斑马鱼胚胎发育中对神经嵴细胞迁移的关键调控作用。
---
**注意**：以上文献为示例，实际引用需查询 PubMed、Web of Science 等数据库获取真实研究。SURF6 相关研究多聚焦于核糖体生成、细胞周期及疾病关联，抗体常被用于定位、表达量检测或功能研究。
The SURF6 antibody is a tool used to study the SURF6 (Surfeit 6) protein, a member of the Surfeit gene cluster. This conserved cluster, found in vertebrates, encodes multiple proteins (SURF1 to SURF6) implicated in diverse cellular processes. SURF6 localizes to the nucleolus and is associated with ribosome biogenesis, specifically in rRNA processing and ribosomal subunit assembly. Its role in cell cycle regulation, proliferation, and potential links to cancer have drawn research interest. Studies suggest SURF6 interacts with nucleolar proteins like NOLC1 and participates in pre-rRNA maturation.
SURF6 antibodies (polyclonal or monoclonal) enable detection and quantification of SURF6 in techniques like Western blotting, immunofluorescence, and immunoprecipitation. These antibodies help explore SURF6's expression patterns across tissues, its subcellular localization, and dysregulation in diseases. Notably, SURF6 overexpression has been observed in certain cancers (e.g., hepatocellular carcinoma), suggesting its potential as a biomarker or therapeutic target. Additionally, research links SURF6 to developmental processes and genetic disorders, though its precise mechanisms remain under investigation. Commercial SURF6 antibodies are often validated for specificity using knockout cell lines or siRNA knockdown. Ongoing studies aim to clarify SURF6's molecular interactions and its broader role in nucleolar function and disease pathology.
×
