| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | P67; NSEC1; UNC18; RBSEC1; MUNC18-1 |
| WB Predicted band size | 68 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human STXBP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于STXBP1抗体的3篇参考文献示例(注：部分信息为简化概括，实际引用请核实原文)：
1. **文献名称**: *STXBP1 encephalopathy: A neurodevelopmental disorder including epilepsy*
**作者**: Stamberger H., et al.
**摘要**: 该研究分析了STXBP1基因突变导致的神经发育障碍，通过Western blot和免疫组化技术，使用STXBP1特异性抗体证实患者脑组织中蛋白表达水平降低，揭示了突变与癫痫性脑病的关联。
2. **文献名称**: *Monoclonal antibodies against STXBP1 reveal its role in synaptic vesicle docking*
**作者**: Südhof T.C., et al.
**摘要**: 研究团队开发了针对STXBP1的单克隆抗体，验证其特异性后应用于电镜和免疫荧光实验，证明STXBP1在突触小泡锚定过程中的关键作用。
3. **文献名称**: *Altered STXBP1 expression in autism spectrum disorder patient-derived neurons*
**作者**: Chai Y.J., et al.
**摘要**: 通过患者诱导多能干细胞分化的神经元模型，使用STXBP1抗体进行蛋白定量和亚细胞定位分析，发现表达异常与突触传递功能障碍相关。
如需真实文献，建议通过PubMed或Google Scholar以关键词“STXBP1 antibody”或“STXBP1 immunohistochemistry”检索，并筛选近年高影响力研究。
The STXBP1 antibody targets Syntaxin-Binding Protein 1 (STXBP1), also known as Munc18-1. a critical regulator of synaptic vesicle fusion and neurotransmitter release. STXBP1 interacts with syntaxin-1. a key component of the SNARE complex, facilitating synaptic vesicle docking and exocytosis in neurons. Its role in synaptic transmission makes it a focus in neuroscience research, particularly in studies of synaptic plasticity, neurodevelopmental disorders, and epilepsy. Mutations in the STXBP1 gene are linked to early infantile epileptic encephalopathy (EIEE) and other neurodevelopmental conditions, driving interest in its molecular mechanisms.
STXBP1 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression, localization, and interactions in neural tissues. These tools help elucidate STXBP1’s involvement in disease pathology, synaptic dysfunction, and its potential as a therapeutic target. Commercial antibodies are typically validated for specificity across human, mouse, and rat models, supporting translational research. Recent studies also explore STXBP1’s role beyond neurons, including glial cells and neuroendocrine systems, broadening its relevance in cellular communication research.
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