| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | NZF3; ZNF387; ZC2HC10 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ST18 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ST18抗体的模拟参考文献示例(内容为虚构，供格式参考)：
1. **文献名称**: "ST18 Antibody as a Novel Biomarker in Triple-Negative Breast Cancer"
**作者**: Li, X. et al.
**摘要**: 研究报道ST18抗体在检测三阴性乳腺癌组织中的高特异性表达，发现ST18蛋白表达水平与肿瘤转移风险呈正相关，提示其作为预后标志物的潜力。
2. **文献名称**: "Development of a Monoclonal ST18 Antibody for Neurodegenerative Disease Research"
**作者**: Müller, S. & Park, J.
**摘要**: 描述一种新型ST18单克隆抗体的开发，验证其在阿尔茨海默病模型小鼠脑组织中的结合能力，证明ST18可能参与tau蛋白异常磷酸化通路。
3. **文献名称**: "ST18-Mediated Apoptosis Regulation in Colorectal Cancer: Insights from Antibody-Based Inhibition"
**作者**: Gupta, R. et al.
**摘要**: 利用ST18抗体阻断实验，揭示ST18通过调控Bcl-2家族蛋白促进结直肠癌细胞凋亡的机制，为靶向治疗提供依据。
4. **文献名称**: "Comparative Analysis of ST18 Antibody Performance in Immunohistochemistry"
**作者**: Watanabe, K. et al.
**摘要**: 对比多种市售ST18抗体的灵敏度和特异性，优化其在多种癌症组织切片中的染色条件，提出标准化检测流程建议。
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**注意**：以上内容为模拟示例，实际文献需通过PubMed、Google Scholar等平台检索关键词(如"ST18 antibody" + "cancer"/"biomarker")。建议结合具体研究领域细化搜索。
The ST18 antibody targets the ST18 (suppression of tumorigenicity 18) protein, a transcription factor implicated in cancer progression and immune regulation. Initially identified for its potential tumor-suppressive role, ST18 has dualistic functions depending on cellular context. Structurally, it contains zinc finger domains, enabling DNA binding and transcriptional modulation. Studies link ST18 to apoptosis, cell proliferation, and inflammation, with overexpression observed in certain cancers like breast and hepatocellular carcinoma, where it may promote tumor aggressiveness. Conversely, other research suggests ST18 acts as a tumor suppressor in pancreatic and gastric cancers by inhibiting oncogenic pathways.
The ST18 antibody is widely used in research to detect protein expression via techniques like Western blot, immunohistochemistry, and immunofluorescence. Its role in immune regulation, particularly in modulating NF-κB signaling and cytokine production, has expanded its relevance to autoimmune and inflammatory diseases. However, conflicting findings about its pro- or anti-tumor effects highlight the complexity of ST18's biological functions. Current investigations focus on clarifying its mechanistic pathways and therapeutic potential. Commercial ST18 antibodies are typically raised against specific epitopes, with validation data critical for ensuring specificity in experimental settings.
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