| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | SSRC; CT5.1 |
| WB Predicted band size | 22 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human SSX1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SSX1抗体的示例参考文献(注：部分信息为示例性质，实际文献需通过学术数据库验证)：
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1. **标题**: *"SSX1 as a diagnostic marker for synovial sarcoma: Development of a novel monoclonal antibody"*
**作者**: Smith A, et al.
**摘要**: 研究团队开发了一种针对SSX1蛋白的单克隆抗体，通过免疫组化验证其在滑膜肉瘤诊断中的特异性。该抗体能有效区分SSX1与其他SSX家族蛋白，并在临床样本中检测到滑膜肉瘤特异性融合蛋白的表达。
2. **标题**: *"Immunodetection of cancer-testis antigen SSX1 in epithelial malignancies"*
**作者**: Lee B, et al.
**摘要**: 本研究利用SSX1抗体探究其在多种上皮源性肿瘤(如肺癌、乳腺癌)中的表达。结果显示，SSX1在部分癌症中异常激活，提示其可能作为免疫治疗靶点或预后标志物。
3. **标题**: *"SSX1 antibody-based detection of minimal residual disease in synovial sarcoma"*
**作者**: Tanaka K, et al.
**摘要**: 通过高灵敏度的SSX1抗体建立了一种检测滑膜肉瘤术后微小残留病灶的方法，证实其在血液和骨髓样本中的诊断潜力，为临床监测复发提供新工具。
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**建议**：如需具体文献，可通过PubMed或Google Scholar搜索关键词“SSX1 antibody”、“SSX1 immunohistochemistry”或“SSX1 cancer”，并筛选近10年研究以获取最新进展。
The SSX1 antibody is a valuable tool in cancer research, particularly in studying malignancies associated with the SSX gene family. SSX1. a member of the SSX (synovial sarcoma X breakpoint) gene family, encodes a cancer-testis antigen (CTA) normally expressed in germ cells but aberrantly reactivated in various cancers. SSX proteins are implicated in transcriptional regulation and chromatin remodeling. SSX1 gained prominence due to its role in synovial sarcoma, where chromosomal translocation t(X;18) fuses SSX1 (or SSX2/SSX4) with the SS18 gene, producing an oncogenic SS18-SSX fusion protein that drives tumorigenesis by disrupting epigenetic regulators.
SSX1 antibodies are primarily used to detect SSX1 protein expression in research and diagnostic settings. They help identify SSX1-positive tumors, characterize subcellular localization (nuclear/cytoplasmic), and study its interaction with proteins like Polycomb repressive complexes. Commercially available SSX1 antibodies include monoclonal and polyclonal variants validated for techniques like immunohistochemistry, Western blotting, and immunofluorescence. Challenges include cross-reactivity with other SSX family members (SSX2-SSX9) due to high sequence homology, necessitating careful validation. Clinically, SSX1 is explored as a biomarker and immunotherapy target, with efforts to develop SSX1-directed CAR-T cells or vaccines. However, its restricted normal tissue expression and tumor-specific reactivation make it a promising but still emerging target in precision oncology.
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