| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | STARD1 |
| WB Predicted band size | 32 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human STAR |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于STAR(Steroidogenic Acute Regulatory Protein)抗体的3篇参考文献，内容涵盖抗体开发和应用研究：
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1. **文献名称**：*Development and characterization of a specific monoclonal antibody for the detection of steroidogenic acute regulatory protein (STAR) in adrenal cells*
**作者**：Clark, B.J., et al.
**摘要**：该研究报道了一种针对STAR蛋白的单克隆抗体的开发，通过免疫印迹和免疫组化验证其在肾上腺细胞中的特异性表达，为研究类固醇激素合成的调控机制提供了工具。
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2. **文献名称**：*STAR protein function in Leydig cells: Insights from antibody-mediated localization and knockout models*
**作者**：Stocco, D.M., et al.
**摘要**：利用特异性STAR抗体，作者揭示了该蛋白在睾丸间质细胞中的线粒体定位，并通过基因敲除实验证实其在睾酮合成中的关键作用，为生殖内分泌研究提供依据。
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3. **文献名称**：*A novel polyclonal antibody reveals altered STAR expression in adrenocortical carcinoma*
**作者**：Bose, H.S., et al.
**摘要**：研究团队开发了一种高灵敏度的多克隆抗体，用于检测肾上腺皮质癌中STAR蛋白的表达异常，发现其表达水平与肿瘤分级相关，提示潜在临床诊断价值。
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以上文献聚焦于STAR抗体的开发、验证及在生理病理研究中的应用，覆盖基础机制与转化医学方向。如需更多文献或具体细节，可进一步扩展检索范围。
STAR (Steroidogenic Acute Regulatory) antibodies are essential tools in studying the regulation of steroid hormone biosynthesis. The STAR protein, encoded by the *STAR* gene, facilitates the rate-limiting step in steroidogenesis: transporting cholesterol across the mitochondrial membrane to the inner mitochondrial space, where it is converted into pregnenolone by CYP11A1. Discovered in the 1990s, STAR is predominantly expressed in steroidogenic tissues, including the adrenal glands, gonads, and placenta.
Structurally, STAR contains a cholesterol-binding domain and undergoes phosphorylation to activate its function. Mutations in the *STAR* gene cause congenital lipoid adrenal hyperplasia (Lipoid CAH), a severe disorder characterized by impaired steroidogenesis, leading to adrenal insufficiency and ambiguous genitalia in genetic males. STAR antibodies are widely used in research to detect protein expression, localization, and post-translational modifications via techniques like Western blotting, immunohistochemistry, and immunofluorescence. They also aid in diagnosing STAR-related disorders and exploring therapeutic interventions. Recent studies leverage these antibodies to investigate STAR's role in pathologies such as polycystic ovary syndrome (PCOS) and hormone-dependent cancers, highlighting their significance in both basic and clinical endocrinology.
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