| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | SVH; PNAS112; PNAS-112; PSEC0198 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human ARMC10 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是几篇关于ARMC10抗体的虚构参考文献示例(请注意，这些为假设性示例，实际文献需通过学术数据库查询)：
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1. **文献名称**: *ARMC10 Antibody Characterization and Its Role in Mitochondrial Dynamics*
**作者**: Lee, S. et al.
**摘要**: 本研究通过开发特异性ARMC10抗体，揭示了ARMC10蛋白在线粒体膜形态调控中的作用，发现其缺失导致线粒体碎片化并影响细胞能量代谢。
2. **文献名称**: *ARMC10 Expression Correlates with Glioblastoma Progression*
**作者**: Zhang, Y. et al.
**摘要**: 利用ARMC10抗体进行免疫组化分析，发现ARMC10在胶质母细胞瘤组织中高表达，且与肿瘤侵袭性和患者预后不良显著相关。
3. **文献名称**: *ARMC10 Interacts with β-Catenin: A Study Using Co-Immunoprecipitation*
**作者**: Gupta, R. et al.
**摘要**: 通过ARMC10抗体进行共免疫沉淀实验，证实ARMC10与β-catenin存在直接相互作用，提示其可能参与Wnt信号通路的调控。
4. **文献名称**: *Development of a Monoclonal ARMC10 Antibody for Flow Cytometry Applications*
**作者**: Müller, J. et al.
**摘要**: 研究团队成功制备了一种高灵敏度ARMC10单克隆抗体，优化其在流式细胞术中的检测条件，并验证了其在T细胞活化中的表达变化。
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如需真实文献，建议访问 **PubMed** 或 **Web of Science**，以关键词“ARMC10 antibody”或“ARMC10 protein function”检索近期研究。
The ARMC10 (Armadillo Repeat Containing 10) protein is a relatively understudied member of the Armadillo (ARM) repeat-containing protein family, characterized by tandem repeats of ~40 amino acid motifs that mediate protein-protein interactions. ARMC10 is evolutionarily conserved and ubiquitously expressed across tissues, with emerging roles in mitochondrial dynamics, cellular metabolism, and apoptosis. Studies suggest its involvement in regulating mitochondrial morphology through interactions with fusion/fission machinery, though its precise molecular mechanisms remain unclear. Dysregulation of ARMC10 has been implicated in cancer progression, neurodegenerative disorders, and metabolic syndromes, highlighting its potential as a therapeutic target.
ARMC10 antibodies are essential tools for investigating its expression, localization, and function. These antibodies, typically developed in rabbit or mouse hosts, enable applications such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and co-immunoprecipitation (Co-IP). Validation data often include reactivity checks across species (human, mouse, rat) and knockdown/knockout controls to confirm specificity. Commercial ARMC10 antibodies are available from suppliers like Sigma-Aldrich, Abcam, and Invitrogen, but batch variability necessitates careful optimization. Recent research employs ARMC10 antibodies to explore its role in tumorigenesis, particularly in modulating mitochondrial apoptosis in cancers, and its interactions with pathways like AMPK/mTOR. Further studies are needed to unravel its multifaceted biological significance and clinical relevance.
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