| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | STX13; STX14 |
| WB Predicted band size | 32 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及STX12(Syntaxin 12)抗体的文献摘要信息：
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1. **文献名称**：*Syntaxin 12 regulates lysosomal degradation pathways*
**作者**：Wang Y. et al. (2018)
**摘要**：研究揭示了STX12在溶酶体降解通路中的作用，通过特异性抗体进行免疫印迹和免疫荧光实验，发现STX12与溶酶体膜蛋白的相互作用影响自噬过程。
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2. **文献名称**：*Characterization of Syntaxin 12 in neuronal vesicle trafficking*
**作者**：Chen L. & Smith C. (2015)
**摘要**：利用STX12抗体进行神经元细胞的亚细胞定位分析，证明STX12参与突触前膜的囊泡运输，并调节神经递质释放效率。
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3. **文献名称**：*STX12 modulates EGFR recycling in cancer cells*
**作者**：Zhang R. et al. (2020)
**摘要**：通过免疫沉淀(IP)结合STX12抗体，发现STX12通过与EGFR结合调控其内吞和再循环，影响肿瘤细胞的增殖和迁移能力。
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**注**：以上文献信息为模拟示例，实际文献需通过PubMed或Google Scholar检索确认。建议结合关键词“STX12 antibody”及研究领域进一步筛选。
STX12 (Syntaxin-12) is a member of the syntaxin family of proteins, which are critical components of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex involved in intracellular membrane fusion and trafficking. Primarily localized to the Golgi apparatus and endosomes, STX12 facilitates vesicle docking and fusion, playing a key role in protein sorting, organelle biogenesis, and retrograde transport. It interacts with other SNARE proteins, such as VAMP4 and SNAP-23. to mediate membrane dynamics essential for maintaining cellular homeostasis.
STX12 has been implicated in various physiological and pathological processes. Studies suggest its involvement in neuronal function, immune response modulation, and cancer progression. For instance, dysregulation of STX12 expression has been observed in certain malignancies, where it may influence tumor cell proliferation, migration, or drug resistance by altering vesicular trafficking pathways. Additionally, STX12 is linked to neurodegenerative disorders, potentially through disruptions in synaptic vesicle recycling or protein aggregation clearance.
Antibodies targeting STX12 are vital tools for investigating its expression, localization, and molecular interactions. They enable techniques like Western blotting, immunofluorescence, and co-immunoprecipitation, aiding in the exploration of STX12’s role in cellular mechanisms and disease contexts. Such research may contribute to identifying therapeutic targets or biomarkers for conditions associated with vesicular transport defects.
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