| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | SYN16 |
| WB Predicted band size | 37 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human STX16 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于STX16抗体的3篇代表性文献的简要信息(注：内容为模拟示例，非真实文献)：
1. **文献名称**：*Role of STX16 in Golgi-lysosome trafficking revealed by antibody-based perturbation*
**作者**：Chen L, et al.
**摘要**：本研究利用特异性STX16抗体阻断其功能，证明Syntaxin 16在溶酶体生成和晚期内体运输中的关键作用，揭示了其与Rab7蛋白的相互作用机制。
2. **文献名称**：*Development of a monoclonal STX16 antibody for detecting autophagy markers in cancer cells*
**作者**：Wang Y, et al.
**摘要**：报道了一种新型STX16单克隆抗体的开发，验证了其在免疫印迹和免疫荧光中的特异性，并发现STX16在乳腺癌细胞自噬过程中表达异常。
3. **文献名称**：*STX16 antibody screening identifies dysregulation in neurodegenerative disorders*
**作者**：Smith J, et al.
**摘要**：通过STX16抗体对阿尔茨海默患者脑组织样本进行分析，发现Syntaxin 16在神经元突触囊泡运输中的功能缺陷可能与tau蛋白病理相关。
(提示：实际文献需通过PubMed或Google Scholar检索关键词如“STX16 antibody”、“Syntaxin 16”+“antibody”获取。)
The STX16 antibody targets Syntaxin-16 (STX16), a member of the Syntaxin family of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). SNARE proteins mediate intracellular membrane fusion events critical for vesicular trafficking, organelle biogenesis, and cargo transport. STX16 localizes primarily to the Golgi apparatus and endosomal compartments, where it regulates retrograde transport, lysosomal function, and autophagy. It interacts with other SNAREs (e.g., VAMP7. SNAP29) and adaptors to form complexes essential for maintaining Golgi structure and secretory pathways. Dysregulation of STX16 has been implicated in diseases such as cancer, neurodegenerative disorders, and lysosomal storage diseases, highlighting its role in cellular homeostasis.
STX16 antibodies are widely used in research to study protein localization, trafficking mechanisms, and disease-associated alterations. Common applications include Western blotting, immunofluorescence, and immunoprecipitation, enabling visualization of STX16 expression patterns in cell lines and tissues. Commercial antibodies are typically raised in rabbits or mice, with validation across multiple experimental platforms. Recent studies also explore STX16's involvement in metabolic signaling and immune responses, expanding its relevance in biomedical research. As a tool, STX16 antibodies contribute to understanding membrane dynamics and developing therapeutic strategies targeting vesicular transport pathways.
×
