| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | TBX7; TBX13 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human TBX10 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TBX10抗体的模拟参考文献示例(仅供学术写作参考，建议通过数据库核实真实文献)：
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1. **文献名称**：*TBX10 Expression in Cardiac Development: Insights from Immunohistochemical Analysis*
**作者**：Li, Y., et al.
**摘要**：本研究利用特异性TBX10抗体，在小鼠胚胎心脏组织中定位TBX10蛋白表达，发现其在心室分隔和瓣膜形成阶段显著上调，提示其在心脏形态发生中的关键作用。
2. **文献名称**：*Characterization of TBX10 Antibody for Molecular Studies in Zebrafish*
**作者**：Smith, J.R., & Tanaka, M.
**摘要**：通过Western blot和免疫荧光验证了TBX10抗体的特异性，并应用于斑马鱼模型，证明TBX10在体节发育和神经嵴细胞迁移中的动态表达模式。
3. **文献名称**：*TBX10 Mutations and Protein Dysregulation in Congenital Scoliosis*
**作者**：Guo, C., et al.
**摘要**：研究结合患者基因测序与TBX10抗体染色，发现TBX10突变导致蛋白稳定性下降，与脊柱发育异常相关，为临床诊断提供了分子标志物。
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**注意**：以上文献信息为模拟示例，实际引用时请通过PubMed或Web of Science等平台检索真实文献。
The TBX10 antibody is a specialized tool used to detect and study the TBX10 protein, a member of the T-box transcription factor family. T-box proteins are evolutionarily conserved regulators of embryonic development, particularly in organogenesis, tissue patterning, and cell differentiation. TBX10. encoded by the *TBX10* gene, plays critical roles in embryonic development, though its specific functions remain less characterized compared to other T-box members like TBX5 or TBX20. Research suggests TBX10 may contribute to heart, limb, and nervous system development, with potential involvement in regulating gene expression networks during morphogenesis.
Antibodies targeting TBX10 are typically generated in immunized animals (e.g., rabbits or mice) using peptide antigens derived from conserved regions of the protein. These antibodies enable researchers to localize TBX10 in tissues (via immunohistochemistry or immunofluorescence), quantify expression levels (via Western blot or ELISA), or study protein-protein interactions (via co-immunoprecipitation). Validation often includes knockout controls or siRNA knockdown to confirm specificity.
TBX10 antibodies are vital for exploring its biological roles, mutations linked to congenital disorders, or its potential dysregulation in diseases. However, challenges like cross-reactivity with homologous T-box proteins require careful experimental design. Commercial TBX10 antibodies vary in clonality (monoclonal/polyclonal), epitope targets, and host species, necessitating selection based on application and validation data.
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