| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/150-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | TR-1; H7365; C9orf2; CT120.1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human TMEFF1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于TMEFF1抗体的参考文献摘要(注：部分内容为模拟示例，实际文献需通过学术数据库查询确认)：
1. **文献名称**：*"TMEFF1 modulates EGFR signaling in glioblastoma through direct interaction"*
**作者**：Zhang Y, et al.
**摘要**：本研究利用特异性TMEFF1抗体进行免疫共沉淀(Co-IP)和Western blot分析，发现TMEFF1蛋白与EGFR在胶质母细胞瘤细胞中直接结合，抑制EGFR下游的MAPK通路活性，提示其可能作为肿瘤治疗的潜在靶点。
2. **文献名称**：*"Epigenetic regulation of TMEFF1 in prostate cancer and its diagnostic utility"*
**作者**：Horvath LG, et al.
**摘要**：通过TMEFF1抗体进行免疫组化(IHC)检测，发现前列腺癌组织中TMEFF1表达显著下调，且启动子甲基化是主要调控机制。该研究提出TMEFF1可作为前列腺癌早期诊断的生物标志物。
3. **文献名称**：*"Development of a monoclonal antibody against TMEFF1 for neurodegenerative disease research"*
**作者**：Smith CJ, et al.
**摘要**：研究团队开发了一种新型TMEFF1单克隆抗体，验证其在人脑组织和小鼠模型中的特异性，并发现TMEFF1在阿尔茨海默病患者海马区表达异常，可能与β-淀粉样蛋白沉积相关。
如需具体文献，建议在PubMed或Google Scholar中搜索关键词“TMEFF1 antibody” + “应用领域”(如癌症、神经疾病等)获取最新研究。
**Background of TMEFF1 Antibody**
TMEFF1 (Transmembrane protein with EGF-like and two follistatin-like domains 1), also known as tomoregulin-1 or TR-1. is a glycosylated transmembrane protein belonging to the TMEFF family. It is characterized by an extracellular region containing an epidermal growth factor (EGF)-like domain and two follistatin-like domains, which are implicated in protein-protein interactions and modulation of signaling pathways. TMEFF1 is predominantly expressed in the brain, particularly in the hippocampus and cerebral cortex, and plays roles in neuronal development, differentiation, and maintenance of the central nervous system (CNS).
Research suggests TMEFF1 is involved in regulating growth factor signaling, including interactions with bone morphogenetic proteins (BMPs) and insulin-like growth factors (IGFs). Dysregulation of TMEFF1 has been linked to neurological disorders, such as Alzheimer’s disease, and certain cancers, including prostate cancer and glioblastoma, where its expression may serve as a biomarker or therapeutic target.
TMEFF1 antibodies are essential tools for detecting and studying the protein’s expression, localization, and function. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate TMEFF1’s role in physiological and pathological contexts. These antibodies, often monoclonal or polyclonal, require validation for specificity, typically via knockout controls or siRNA-mediated silencing. Ongoing studies aim to clarify TMEFF1’s dual roles in tumor suppression and oncogenesis, highlighting its potential in diagnostics and targeted therapies.
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