| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human TMPRSS11B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TMPRSS11B抗体的3篇参考文献示例(注：部分文献信息为假设性描述，实际引用请核实)：
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1. **文献名称**: *TMPRSS11B protease activation and antibody characterization in lung cancer*
**作者**: Smith A, et al.
**摘要**: 本研究开发了一种特异性识别TMPRSS11B的兔源多克隆抗体，验证其通过免疫组化在肺癌组织中的表达定位，并发现其高表达与患者预后不良相关。
2. **文献名称**: *Role of TMPRSS11B in SARS-CoV-2 entry and neutralizing antibody screening*
**作者**: Lee J, et al.
**摘要**: 利用抗TMPRSS11B单克隆抗体阻断病毒刺突蛋白的切割，发现其抑制新冠病毒进入宿主细胞的机制，为抗病毒治疗提供潜在靶点。
3. **文献名称**: *Development of a TMPRSS11B-specific monoclonal antibody for functional studies*
**作者**: Chen X, et al.
**摘要**: 报道了一种新型小鼠单克隆抗体的制备及验证，该抗体通过Western blot和免疫荧光证实与TMPRSS11B蛋白特异性结合，并用于研究其在呼吸道上皮细胞中的功能。
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**备注**：以上文献为示例，真实文献需通过PubMed或学术数据库检索。建议使用关键词“TMPRSS11B antibody”或结合研究领域(如癌症、病毒感染)进行精准查询。
TMPRSS11B, a member of the type II transmembrane serine protease (TTSP) family, is encoded by the *TMPRSS11B* gene located on human chromosome 4q13.3. These proteases are characterized by a transmembrane domain, a stem region, and a C-terminal catalytic domain, and are involved in proteolytic processing of proteins, cell signaling, and tissue homeostasis. TMPRSS11B is primarily expressed in epithelial tissues, including the respiratory tract, and may play roles in mucosal defense, viral entry facilitation, and extracellular matrix remodeling. Its enzymatic activity is regulated by endogenous inhibitors like hepatocyte growth factor activator inhibitor (HAI-1/2).
Antibodies targeting TMPRSS11B are valuable tools for studying its expression, localization, and function in physiological and pathological contexts. They are used in techniques such as Western blotting, immunohistochemistry, and flow cytometry to explore its role in diseases like cancer, respiratory infections, and inflammatory disorders. For instance, TMPRSS11B has been implicated in SARS-CoV-2 infection due to its potential to cleave viral spike proteins, similar to TMPRSS2. However, its precise mechanisms remain less characterized compared to other TTSPs. Research-grade antibodies are typically validated for specificity using knockout controls to minimize cross-reactivity with homologous proteases. Therapeutic applications, such as neutralizing antibodies to block protease activity, are under exploration but require further validation. Challenges include optimizing antibody selectivity and understanding isoform-specific functions, given the gene’s alternative splicing variants. Overall, TMPRSS11B antibodies are critical for elucidating its biological significance and translational potential.
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