| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | SPINESIN |
| WB Predicted band size | 50 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human TMPRSS5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3条关于TMPRSS5抗体的模拟参考文献示例(注：以下内容为虚构，仅用于演示格式，实际文献请通过学术数据库检索)：
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1. **文献名称**: *TMPRSS5 as a Novel Serine Protease Target in Prostate Cancer*
**作者**: Smith J, et al.
**摘要**: 研究开发了针对TMPRSS5的单克隆抗体，验证其在前列腺癌细胞系中的特异性结合能力，并证明其可通过抑制TMPRSS5的蛋白酶活性抑制肿瘤侵袭转移。
2. **文献名称**: *Structural Characterization of TMPRSS5 Antibodies for Therapeutic Applications*
**作者**: Lee H, et al.
**摘要**: 通过X射线晶体学解析了TMPRSS5与抗体复合物的结构，揭示了抗体结合表位的关键区域，为设计靶向TMPRSS5的抗体药物提供结构基础。
3. **文献名称**: *TMPRSS5 Antibody-Based Biomarker Detection in Colorectal Cancer*
**作者**: Garcia R, et al.
**摘要**: 利用抗TMPRSS5多克隆抗体开发了ELISA检测方法，发现结直肠癌患者血清中TMPRSS5水平显著升高，提示其作为潜在诊断标志物的价值。
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建议通过PubMed、Web of Science或Google Scholar检索关键词“TMPRSS5 antibody”获取真实文献。
**Background of TMPRSS5 Antibody**
TMPRSS5 (Transmembrane Serine Protease 5), also known as spinesin, is a member of the type II transmembrane serine protease (TTSP) family. These proteases are characterized by a transmembrane domain, a stem region, and a C-terminal catalytic serine protease domain. TMPRSS5 is primarily expressed in the central nervous system, though studies suggest its presence in other tissues, including the prostate and certain cancers. Its physiological roles remain under investigation, but TTSPs are broadly implicated in extracellular matrix remodeling, cell signaling, and tissue homeostasis.
TMPRSS5 antibodies are immunological tools developed to detect and study the expression, localization, and function of the TMPRSS5 protein. These antibodies are critical in research applications such as immunohistochemistry (IHC), Western blotting, and immunofluorescence, enabling insights into TMPRSS5's involvement in diseases. For instance, aberrant TMPRSS5 expression has been linked to cancer progression, particularly in prostate and brain tumors, where it may influence tumor invasiveness or metastasis.
Current research focuses on characterizing TMPRSS5's substrate specificity, regulatory mechanisms, and potential as a therapeutic target or biomarker. However, challenges persist, including the need for validated antibodies with high specificity due to homology among TTSPs. Monoclonal and polyclonal TMPRSS5 antibodies are continuously refined to improve accuracy in experimental models, aiding mechanistic studies and translational applications in oncology and neurology.
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