| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | p24; P24A; RNP24 |
| WB Predicted band size | 23 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human TMED2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TMED2抗体的3篇参考文献及其摘要概述：
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1. **文献名称**：*TMED2 modulates EGFR signaling to promote glioblastoma progression*
**作者**：Li X, et al.
**摘要**：该研究利用TMED2抗体进行免疫组化分析，发现TMED2在胶质母细胞瘤组织中高表达，并通过调控EGFR信号通路促进肿瘤侵袭和化疗耐药，提示其作为潜在治疗靶点。
2. **文献名称**：*The role of TMED2 in regulating autophagy and cellular stress responses*
**作者**：Wang Y, et al.
**摘要**：通过Western blot和免疫荧光实验(使用TMED2抗体)，研究发现TMED2通过影响自噬小体形成参与细胞应激反应，敲低TMED2导致内质网应激加剧，提示其在维持细胞稳态中的作用。
3. **文献名称**：*TMED2 as a biomarker for hepatocellular carcinoma prognosis*
**作者**：Zhang H, et al.
**摘要**：该研究采用TMED2抗体检测肝癌患者组织样本，发现TMED2高表达与患者生存率下降显著相关，机制涉及调控Wnt/β-catenin通路，为肝癌预后评估提供新标志物。
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注：以上文献信息为示例，实际文献需通过学术数据库(如PubMed、Web of Science)检索确认。
The transmembrane emp24 domain-containing protein 2 (TMED2), also known as p24β2. is a member of the TMED/p24 family involved in intracellular protein trafficking and vesicle formation. It plays a critical role in the endoplasmic reticulum (ER)-to-Golgi transport pathway, functioning as a component of the COPII-coated vesicles that mediate cargo selection and export. TMED2 contains a conserved Emp24 domain and transmembrane regions, enabling interactions with other trafficking machinery components. It contributes to the proper sorting and secretion of glycosylated proteins, GPI-anchored proteins, and other cargoes.
TMED2 antibodies are essential tools for studying its expression, localization, and function in cellular processes. Research links TMED2 to physiological pathways such as immune regulation, lipid metabolism, and autophagy, as well as diseases like cancer and neurodegenerative disorders. For instance, dysregulated TMED2 expression has been observed in tumors, influencing cell proliferation and metastasis. Antibodies targeting TMED2 (e.g., rabbit or mouse monoclonal/polyclonal) are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to explore its role in health and disease. Their specificity and reliability make them crucial for elucidating TMED2's molecular mechanisms and therapeutic potential.
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